Enantioselective Synthesis of the ent-Lomaiviticin A Bicyclic Core

Enantioselective Synthesis of the ent-Lomaiviticin A Bicyclic Core

The bicyclic core of ent-lomaiviticin A was prepared in 11 operations from (S)-1-phenyl-2-propyn-1-ol in a two-directional route that features (1) a double Ireland Claisen rearrangement and (2) a double olefin metathesis reaction to form the key C–C bonds of the target.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2012-11, Vol.14 (21), p.5484-5487
Hauptverfasser: Feldman, Ken S, Selfridge, Brandon R
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Fluorenes - chemical synthesis
Fluorenes - chemistry
Molecular Structure
Stereoisomerism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The bicyclic core of ent-lomaiviticin A was prepared in 11 operations from (S)-1-phenyl-2-propyn-1-ol in a two-directional route that features (1) a double Ireland Claisen rearrangement and (2) a double olefin metathesis reaction to form the key C–C bonds of the target.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol302567f