A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library

A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library

Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydr...

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Veröffentlicht in:Organic letters 2012-11, Vol.14 (21), p.5404-5407
Hauptverfasser: Hamieh, Saleh, Ludlow, R. Frederick, Perraud, Olivier, West, Kevin R, Mattia, Elio, Otto, Sijbren
Format: Artikel
Sprache:eng
Schlagworte:
Combinatorial Chemistry Techniques
Hydrogen-Ion Concentration
Molecular Structure
Nicotine - chemistry
Nuclear Magnetic Resonance, Biomolecular
Thermodynamics
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Zusammenfassung:Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and π–π interactions.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol302260n