The centrosomal protein tax1 binding protein 2 is a novel tumor suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2

Deregulation of cellular‐signaling pathways by the inactivation of tumor‐suppressor genes is one of the major causes of hepatocellular carcinoma (HCC). In this study, we identified Tax1 binding protein 2 (TAX1BP2) as a novel tumor‐suppressor gene in HCC. TAX1BP2 transcript was frequently underexpres...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2012-11, Vol.56 (5), p.1770-1781
Hauptverfasser:	Lai, Wai-Lung, Hung, Wing-Yan, Wong, Leo Lap-Yan, Zhou, Yuan, Leong, Veronica Yee-Law, Lee, Joyce Man-Fong, Ng, Irene Oi-Lin, Jin, Dong-Yan, Ching, Yick-Pang
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Centrosome - metabolism Cyclin-Dependent Kinase 2 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-dependent kinases Down-Regulation Gene Expression Regulation, Neoplastic Gene Silencing Hep G2 Cells Hepatology Humans Kaplan-Meier Estimate Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology MAP Kinase Signaling System - genetics Membrane Proteins - genetics Membrane Proteins - metabolism Phosphorylation Proteins Tumor Suppressor Protein p53 - metabolism
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Zusammenfassung:	Deregulation of cellular‐signaling pathways by the inactivation of tumor‐suppressor genes is one of the major causes of hepatocellular carcinoma (HCC). In this study, we identified Tax1 binding protein 2 (TAX1BP2) as a novel tumor‐suppressor gene in HCC. TAX1BP2 transcript was frequently underexpressed (42.2% with T/NT
ISSN:	0270-9139 1527-3350
DOI:	10.1002/hep.25851