Potentiation of Hemostimulating Effects of Erythropoietin with Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase

Potentiation of Hemostimulating Effects of Erythropoietin with Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase

Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensifi cation of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-indu...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2012-09, Vol.153 (5), p.684-688
Hauptverfasser: Dygai, A. M., Zyuz’kov, G. N., Zhdanov, V. V., Udut, E. V., Gurto, R. V., Miroshnichenko, L. A., Simanina, E. V., Khrichkova, T. Iu, Stavrova, L. A., Chaikovsky, A. V., Artamonov, A. V., Bekarev, A. A., Madonov, P. G., Minakova, M. Iu, Markova, T. S.
Format: Artikel
Sprache:eng
Schlagworte:
Anemia - drug therapy
Animals
beta-N-Acetylhexosaminidases - metabolism
Biomedical and Life Sciences
Biomedicine
Carboplatin
Cell Biology
Dose-Response Relationship, Drug
Drug Synergism
Enzyme-Linked Immunosorbent Assay
Enzymes
Erythrocyte Count
Erythropoietin
Erythropoietin - blood
Erythropoietin - metabolism
Erythropoietin - pharmacology
Female
Hemoglobins - metabolism
Hyaluronic acid
Internal Medicine
Laboratory Medicine
Male
Mice
Mice, Inbred CBA
Nanotechnology - methods
Pathology
Pharmacology and Toxicology
Physiological aspects
Polyethylene Glycols - metabolism
Recombinant Proteins
Statistics, Nonparametric
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Zusammenfassung:Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensifi cation of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-inducing environment cells and elevation of serum erythropoietin concentration. The use of the enzyme allows 10-fold reduction of the maximum effective erythropoietin dose.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1799-0