pH-Responsive Size-Tunable Self-Assembled DNA Dendrimers

pH-Responsive Size-Tunable Self-Assembled DNA Dendrimers

Putting the DNA in dendrimers: A strategy to swiftly prepare DNA dendrimers based solely on DNA self‐assembly is presented. This technique produces highly pure DNA dendrimers with an excellent yield of high generation dendrimers. The incorporation of molecular motors (i‐motifs) into the DNA dendrime...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-11, Vol.51 (45), p.11271-11274
Hauptverfasser: Zhou, Tao, Chen, Ping, Niu, Lin, Jin, Juan, Liang, Dehai, Li, Zhibo, Yang, Zhongqiang, Liu, Dongsheng
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
Circular Dichroism
dendrimers
Dendrimers - chemical synthesis
Dendrimers - chemistry
DNA
DNA - chemical synthesis
DNA - chemistry
Electrophoresis, Agar Gel
Hydrogen-Ion Concentration
Light
Molecular Sequence Data
Nucleic Acid Conformation
pH responsiveness
Scattering, Radiation
self-assembly
size tunable
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Zusammenfassung:Putting the DNA in dendrimers: A strategy to swiftly prepare DNA dendrimers based solely on DNA self‐assembly is presented. This technique produces highly pure DNA dendrimers with an excellent yield of high generation dendrimers. The incorporation of molecular motors (i‐motifs) into the DNA dendrimers allows for a change in size (up to 30%) in response to changing pH values (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201205862