Rational engineering of Candida antarcticalipase B for selective monoacylation of diols

Rational engineering of Candida antarcticalipase B for selective monoacylation of diols

The enzyme Candida antarcticalipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-09, Vol.48 (80), p.10013-10015
Hauptverfasser: Hamberg, Anders, Maurer, Steffen, Hult, Karl
Format: Artikel
Sprache:eng
Schlagworte:
Candida
Chemical communication
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Zusammenfassung:The enzyme Candida antarcticalipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc34684b