Incorporation of Penicillin-Producing Fungi into Living Materials to Provide Chemically Active and Antibiotic-Releasing Surfaces

Living materials: Artificial biological niches are loaded with the penicillin‐producing mold Penicillium chrysogenum. This living material consumes food through a nanoporous top layer and releases the antibiotic on‐site. No reloading of the active compound is needed. Gram‐positive bacteria were efficiently killed if nearby, whereas Gram‐negative bacteria (control experiment, not sensitive to penicillin) were not affected.