ARID1A expression loss in gastric cancer: pathway-dependent roles with and without Epstein–Barr virus infection and microsatellite instability

The AT-rich interactive domain 1A gene (ARID1A), which encodes one of the subunits in the Switch/Sucrose Nonfermentable chromatin remodeling complex, carries mutations and is responsible for loss of protein expression in gastric carcinoma, particularly with Epstein–Barr virus (EBV) infection and a m...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2012-10, Vol.461 (4), p.367-377
Hauptverfasser:	Abe, Hiroyuki, Maeda, Daichi, Hino, Rumi, Otake, Yuya, Isogai, Maya, Ushiku, Aya Shinozaki, Matsusaka, Keisuke, Kunita, Akiko, Ushiku, Tetsuo, Uozaki, Hiroshi, Tateishi, Yoko, Hishima, Tsunekazu, Iwasaki, Yoshiaki, Ishikawa, Shumpei, Fukayama, Masashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - mortality Aged Biological and medical sciences Carcinogenesis Cell Line, Tumor Chromatin remodeling Disease Progression DNA, Neoplasm - genetics Down-Regulation - genetics Down-Regulation - physiology Epithelial cells Epstein-Barr virus Epstein-Barr Virus Infections - genetics Epstein-Barr Virus Infections - physiopathology Female Gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Histology Humans Immunohistochemistry Infection Infectious diseases Investigative techniques, diagnostic techniques (general aspects) Lymph nodes Lymphatic Metastasis - genetics Lymphatic Metastasis - physiopathology Lymphoma Lymphoma - genetics Lymphoma - metabolism Male Medical sciences Medicine Medicine & Public Health Metastases Microsatellite Instability Microsatellites Middle Aged MLH1 protein Mutation MutL Protein Homolog 1 Nasopharyngeal carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Original Article Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis Retrospective Studies Signal Transduction - genetics Signal Transduction - physiology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Sucrose Survival Rate Transcription Factors - genetics Transcription Factors - metabolism Tumor cell lines Tumors Viral diseases
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Zusammenfassung:	The AT-rich interactive domain 1A gene (ARID1A), which encodes one of the subunits in the Switch/Sucrose Nonfermentable chromatin remodeling complex, carries mutations and is responsible for loss of protein expression in gastric carcinoma, particularly with Epstein–Barr virus (EBV) infection and a microsatellite instability-high phenotype. We used immunohistochemistry to investigate the significance of ARID1A loss in 857 gastric carcinoma cases, including 67 EBV(+) and 136 MLH1-lost gastric carcinomas (corresponding to a microsatellite instability-high phenotype). Loss of ARID1A expression was significantly more frequent in EBV(+) (23/67; 34 %) and MLH1-lost (40/136; 29 %) gastric carcinomas than in EBV(−)MLH1-preserved (32/657; 5 %) gastric carcinomas ( P
ISSN:	0945-6317 1432-2307
DOI:	10.1007/s00428-012-1303-2