Hydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats: A stereological and biochemical study

The aim of this study was to investigate the role of hydroxychloroquine (HCQ)-induced oxidative stress on sciatic nerve and muscle tissues of rats. The oxidant/antioxidant parameters in the sciatic nerve and muscle tissues were analyzed, and stereological analysis of the sciatic nerve was performed....

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Veröffentlicht in:	Human & experimental toxicology 2012-10, Vol.31 (10), p.1066-1073
Hauptverfasser:	Uzar, E, Ozay, R, Evliyaoglu, O, Aktas, A, Ulkay, MB, Uyar, ME, Ersoy, A, Burakgazi, AZ, Turkay, C, Ilhan, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - toxicity Aryldialkylphosphatase - metabolism Atrophy Biochemistry Biological and medical sciences Biomarkers - metabolism Glutathione Peroxidase - metabolism Hydroxychloroquine - toxicity Male Malondialdehyde - metabolism Medical sciences Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscular system Nervous system Nitric oxide Nitric Oxide - metabolism Oxidative stress Oxidative Stress - drug effects Pharmacology Rats Rats, Wistar Rodents Sciatic Nerve - drug effects Sciatic Nerve - metabolism Sciatic Nerve - pathology Superoxide Dismutase - metabolism Toxicity Toxicology
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Zusammenfassung:	The aim of this study was to investigate the role of hydroxychloroquine (HCQ)-induced oxidative stress on sciatic nerve and muscle tissues of rats. The oxidant/antioxidant parameters in the sciatic nerve and muscle tissues were analyzed, and stereological analysis of the sciatic nerve was performed. Levels of malondialdehyde and nitric oxide in the tissues were significantly higher in the HCQ group than in the control group (p
ISSN:	0960-3271 1477-0903
DOI:	10.1177/0960327111433183