MRI-based clinical trials in relapsing–remitting MS: new sample size calculations based on a longitudinal model

Background: Sample sizes for magnetic resonance imaging (MRI)-based clinical trials in multiple sclerosis (MS) generally assume that lesion counts are reasonably described by the negative binomial (NB) model. Objective: This study aimed to assess the appropriateness of the NB model for lesion count...

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Veröffentlicht in:	Multiple sclerosis 2012-11, Vol.18 (11), p.1600-1608
Hauptverfasser:	Altman, RM, Petkau, AJ, Vrecko, D, Smith, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Brain - pathology Chi-Square Distribution Computer Simulation Controlled Clinical Trials as Topic - methods Controlled Clinical Trials as Topic - statistics & numerical data Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Endpoint Determination Humans Longitudinal Studies Magnetic Resonance Imaging Medical sciences Models, Statistical Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Multiple Sclerosis, Relapsing-Remitting - diagnosis Multiple Sclerosis, Relapsing-Remitting - pathology Multiple Sclerosis, Relapsing-Remitting - therapy Neurology Predictive Value of Tests Sample Size Time Factors Treatment Outcome
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