C-Phycocyanin protects SH-SY5Y cells from oxidative injury, rat retina from transient ischemia and rat brain mitochondria from Ca2+ /phosphate-induced impairment

Highlights ► C-Phycocyanin (C-PC) prevented tert -butylhydroperoxide injury in SH-SY5Y cells. ► C-PC protected the retina against elevated intraocular pressure-induced ischemia. ► C-PC protected brain mitochondria from calcium/phosphate induced impairment. ► C-PC inhibited the Fenton reaction indica...

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Veröffentlicht in:	Brain research bulletin 2012-12, Vol.89 (5), p.159-167
Hauptverfasser:	Marín-Prida, Javier, Pentón-Rol, Giselle, Rodrigues, Fernando Postalli, Alberici, Luciane Carla, Stringhetta, Karina, Leopoldino, Andréia Machado, Naal, Zeki, Polizello, Ana Cristina Morseli, Llópiz-Arzuaga, Alexey, Rosa, Marcela Nunes, Liberato, José Luiz, Santos, Wagner Ferreira dos, Uyemura, Sergio Akira, Pentón-Arias, Eduardo, Curti, Carlos, Pardo-Andreu, Gilberto L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant Brain - drug effects Brain - metabolism C-Phycocyanin Calcium Phosphates - toxicity Cell Line, Tumor Humans Ischemia - chemically induced Ischemia - metabolism Ischemia - prevention & control Male Mitochondria - drug effects Mitochondria - metabolism Neurology Neuroprotection Oxidative Stress - drug effects Oxidative Stress - physiology Phycocyanin - pharmacology Phycocyanin - therapeutic use Rat brain mitochondria Rats Rats, Wistar Reactive Oxygen Species - metabolism Retina - drug effects Retina - metabolism Retinal Vessels - drug effects Retinal Vessels - metabolism SH-SY5Y tert-Butylhydroperoxide - toxicity Transient rat retinal ischemia
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Zusammenfassung:	Highlights ► C-Phycocyanin (C-PC) prevented tert -butylhydroperoxide injury in SH-SY5Y cells. ► C-PC protected the retina against elevated intraocular pressure-induced ischemia. ► C-PC protected brain mitochondria from calcium/phosphate induced impairment. ► C-PC inhibited the Fenton reaction indicating the antioxidant effect of the drug.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2012.08.011