Combined Liver-Intestine Grafts Compared With Isolated Intestinal Transplantation in Children: A Single-Center Experience

Combined Liver-Intestine Grafts Compared With Isolated Intestinal Transplantation in Children: A Single-Center Experience

Intestinal transplantation is known to be associated with a high risk of early complications and mortality. We analyzed prospective data of 51 primary small bowel transplantations from December 1999 to August 2009 and identified perioperative factors that impact on early mortality (≤6 months after t...

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Veröffentlicht in:Transplantation 2012-10, Vol.94 (8), p.859-865
Hauptverfasser: DOPAZO, Cristina, GUPTE, Girish L, MOURIK, Indra Van, MCKIERNAN, Patrick, BEATH, Sue V, MIRZA, Darius F, SHARIF, Khalid, PERERA, M. Thamara Pr, HARTLEY, Jane, MUIESAN, Paolo, MAYER, David A, BROMLEY, Peter, BENNETT, John, KELLY, Deidre A
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Biological and medical sciences
Blood Platelets - physiology
Child
Child, Preschool
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
General aspects
Graft Rejection
Humans
Infant
Intestines - transplantation
Kidney - physiopathology
Liver - physiopathology
Liver Transplantation - mortality
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
Postoperative Complications - epidemiology
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Tissue, organ and graft immunology
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Zusammenfassung:Intestinal transplantation is known to be associated with a high risk of early complications and mortality. We analyzed prospective data of 51 primary small bowel transplantations from December 1999 to August 2009 and identified perioperative factors that impact on early mortality (≤6 months after transplantation) after isolated intestinal (IITx; n=12) and combined liver-intestinal transplantation (CLITx group; n=39). Ten patients died during the first 6 months after transplantation, all of them in CLITx group (n=10/51, 19%). Multivariate analyses demonstrated intraoperative red blood cell transfusion greater than 70 mL/kg (P=0.019, odds ratio [OR]=13.79) and base excess 30-min after reperfusion less than -16 (P=0.001, OR=14.05), thrombocytopenia (
ISSN:0041-1337
1534-6080
DOI:10.1097/TP.0b013e318265c508