Immunologic Response to Hepatitis B Vaccine in Health Care Workers: A Screening Program and Evaluation of Some Host-Related Factors Role

Problem statement: To evaluation the immunologic response to hepatitis B vaccine in health care's workers and effects of host-related factors? Approach: In a cross sectional descriptive analytic study carried out on the medical staffof Tabriz Shahid Madani Hospital in 2009-2010, we evaluated the immunologic response of the staffto vaccination against Hepatitis B and factors affecting it. Results: The mean antibody titer in the studied medical staffwas 366.76 plus or minus 169.714 IU L super( -1). 2.05% were in "no response" group, 1.46% in "Low response" group and 96.49% in "Good response" group. Conclusion: Immunological response in the smoking staffwas significantly less (p < 0.001) but no significant difference was observed in the response between genders (p = 0.127) and no case of hyperlipidemia was reported. There was a significant reverse linear relation between age and antibody titer in the studied staff(p = 0.003, R = 0.162) but no significant linear relation was observed between weight, height and BMI and antibody titer.