Vectored Immunoprophylaxis - An Innovative Approach to Prevent HIV Infection

Despite the numerous efforts made to develop an effective vaccine, immunization against HIV infection remains an elusive goal. Vaccine trials performed to date have shown either no efficacy or even a trend towards a higher infection in the vaccinated population (Cohen, et al. Science. 2007; 318(5853): 1048-9). The only exception was reported by the so-called "Thai Trial", which showed a protective effect in 31% of individuals receiving the combined vaccine RV144 (Rerks-Ngarm, et al. New Engl J Med. 2009; 361(23): 2209-20). This rate of protective effect, although significant and encouraging for the HIV vaccination field, is far from desirable to provide a global effective protection.