Maintaining Poise: Commensal Microbiota Calibrate Interferon Responses

Maintaining Poise: Commensal Microbiota Calibrate Interferon Responses

The mechanisms of how commensal bacteria impact systemic immunity are unclear. In this issue of Immunity, Abt et al. (2012) and Ganal et al. (2012) demonstrate that microbiota poise macrophages for induction of the type I interferon pathway after virus infection.

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Bibliographische Detailangaben
Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 2012-07, Vol.37 (1), p.10-12
Hauptverfasser: McAleer, Jeremy P., Kolls, Jay K.
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Bacteria
Commensals
Cytotoxicity
DNA methylation
Epigenetics
Gene expression
HIV
Human immunodeficiency virus
Immune system
Immunity
Infection
Infections
Interferon
Macrophages
Phosphorylation
RNA polymerase
Studies
Transcription factors
Viral infections
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Beschreibung
Zusammenfassung:The mechanisms of how commensal bacteria impact systemic immunity are unclear. In this issue of Immunity, Abt et al. (2012) and Ganal et al. (2012) demonstrate that microbiota poise macrophages for induction of the type I interferon pathway after virus infection.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2012.07.001