Tumor characteristics and recurrence patterns in triple negative breast cancer: A comparison between younger (<65) and elderly (⩾65) patients

Abstract Background In an aging population an increasing number of breast cancers is diagnosed in elderly women. Tumor characteristics and patterns of metastasation have been extensively elucidated in younger triple negative breast cancer (TNBC) patients, but data regarding TNBC in elderly women are...

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Veröffentlicht in:	European journal of cancer (1990) 2012-11, Vol.48 (16), p.2962-2968
Hauptverfasser:	Königsberg, Robert, Pfeiler, Georg, Klement, Tatjana, Hammerschmid, Nicole, Brunner, Andreas, Zeillinger, Robert, Singer, Christian, Dittrich, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Austria Biological and medical sciences Biomarkers, Tumor - analysis Bone metastases Bone Neoplasms - secondary Brain Neoplasms - secondary Breast Neoplasms - chemistry Breast Neoplasms - pathology Breast Neoplasms - therapy Carcinoma - chemistry Carcinoma - secondary Carcinoma - therapy Chemotherapy Chemotherapy, Adjuvant Chi-Square Distribution Elderly Female Hematology, Oncology and Palliative Medicine Humans Liver Neoplasms - secondary Local recurrence Lung Neoplasms - secondary Lymph node metastases Lymphatic Metastasis Mastectomy Medical sciences Middle Aged Neoadjuvant Therapy Neoplasm Grading Neoplasm Recurrence, Local Pharmacology. Drug treatments Radiotherapy, Adjuvant Receptor, ErbB-2 - analysis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome Triple negative breast cancer Tumor Burden Tumors
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Zusammenfassung:	Abstract Background In an aging population an increasing number of breast cancers is diagnosed in elderly women. Tumor characteristics and patterns of metastasation have been extensively elucidated in younger triple negative breast cancer (TNBC) patients, but data regarding TNBC in elderly women are missing. The goal of this investigation was to compare clinical pathological characteristics of younger and elderly TNBC patients in order to assess their relevance for TNBC in an aging population. Methods Data of TNBC patients diagnosed between 1998 and 2004 were retrospectively analyzed by computer based chart information. Baseline tumor characteristics, patient demographics and patterns of metastasation were compared between younger (
ISSN:	0959-8049 1879-0852
DOI:	10.1016/j.ejca.2012.04.019