Genetic Variants of the Renin-Angiotensin-Aldosterone System and Reverse Remodeling After Cardiac Resynchronization Therapy
Abstract Background Reverse remodeling (RR) after cardiac resynchronization therapy (CRT) is associated with favorable clinical outcomes in heart failure (HF). The renin-angiotensin-aldosterone system (RAAS) is involved in the remodeling process. Methods and Results We assessed the association betwe...
Gespeichert in:
| Veröffentlicht in: | Journal of cardiac failure 2012-10, Vol.18 (10), p.762-768 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 768 |
|---|---|
| container_issue | 10 |
| container_start_page | 762 |
| container_title | Journal of cardiac failure |
| container_volume | 18 |
| creator | De Maria, Renata, MD Landolina, Maurizio, MD Gasparini, Maurizio, MD Schmitz, Boris, PhD Campolo, Jonica, MSc Parolini, Marina, BStat Sanzo, Antonio, MD Galimberti, Paola, MD Bianchi, Michele, MD Brand, Stefan-Martin, MD, PhD Parodi, Oberdan, MD Lunati, Maurizio, MD |
| description | Abstract Background Reverse remodeling (RR) after cardiac resynchronization therapy (CRT) is associated with favorable clinical outcomes in heart failure (HF). The renin-angiotensin-aldosterone system (RAAS) is involved in the remodeling process. Methods and Results We assessed the association between RR and 8 common RAAS gene variants, which were determined by TaqMan assays, in 156 outpatients with chronic HF. RR was defined as a >15% decrease in left ventricular end systolic volume (LVESV) at 9 (interquartile range 7–12) months after CRT. We matched 76 patients who did not show RR (RR−) to 80 RR+ control subjects by age, sex, HF etiology, New York Heart Association (NYHA) functional class and left ventricular ejection fraction (LVEF). The frequency of the minor allele of the NR3C2 gene (rs5522 C/T), encoding the mineralocorticoid receptor, was higher in RR− than in RR (24/126 vs 10/150; P value after false discovery rate correction: |
| doi_str_mv | 10.1016/j.cardfail.2012.07.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1095456393</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1071916412008068</els_id><sourcerecordid>1095456393</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-813e84859b875c14f1e95c8832de5b318ce7041d5210f69797da3c71a30bc4883</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhiMEoqXwClWOXBI8sZM4F8RqVVqkSki0cLW89qTrJbEXO1spiIfhWfpkTLQtBy6cPJK_f8b-JsvOgZXAoHm3K42OttduKCsGVcnakjH5LDuFmleFFCCeU81aKDpoxEn2KqUdI0Kw9mV2UnEmGACcZr8u0ePkTP5NR6f9lPLQ59MW8y_onS9W_s6FCX1a6sGGNGEMHvObmarx4bf2lsh7jGlJjMHi4PxdvuqJy9f0QqcNXaTZmy0F3U89ueDz2y1GvZ9fZy96PSR883ieZV8_Xtyur4rrz5ef1qvrwoiKT4UEjlLIutvItjYgesCuNlLyymK94SANtkyArStgfdO1XWs1Ny1ozjZGEHeWvT323cfw44BpUqNLBodBewyHpIB1tagb3nFCmyNqYkgpYq_20Y06zgSpxbzaqSfzajGvWKvIKwXPH2ccNiPav7En1QR8OAJIP713GFUyDr1B6yKaSdng_j_j_T8tDOl2Rg_fcca0C4foyaMClSijbpb9L-uHitKskfwPJ1-unA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1095456393</pqid></control><display><type>article</type><title>Genetic Variants of the Renin-Angiotensin-Aldosterone System and Reverse Remodeling After Cardiac Resynchronization Therapy</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>De Maria, Renata, MD ; Landolina, Maurizio, MD ; Gasparini, Maurizio, MD ; Schmitz, Boris, PhD ; Campolo, Jonica, MSc ; Parolini, Marina, BStat ; Sanzo, Antonio, MD ; Galimberti, Paola, MD ; Bianchi, Michele, MD ; Brand, Stefan-Martin, MD, PhD ; Parodi, Oberdan, MD ; Lunati, Maurizio, MD</creator><creatorcontrib>De Maria, Renata, MD ; Landolina, Maurizio, MD ; Gasparini, Maurizio, MD ; Schmitz, Boris, PhD ; Campolo, Jonica, MSc ; Parolini, Marina, BStat ; Sanzo, Antonio, MD ; Galimberti, Paola, MD ; Bianchi, Michele, MD ; Brand, Stefan-Martin, MD, PhD ; Parodi, Oberdan, MD ; Lunati, Maurizio, MD</creatorcontrib><description>Abstract Background Reverse remodeling (RR) after cardiac resynchronization therapy (CRT) is associated with favorable clinical outcomes in heart failure (HF). The renin-angiotensin-aldosterone system (RAAS) is involved in the remodeling process. Methods and Results We assessed the association between RR and 8 common RAAS gene variants, which were determined by TaqMan assays, in 156 outpatients with chronic HF. RR was defined as a >15% decrease in left ventricular end systolic volume (LVESV) at 9 (interquartile range 7–12) months after CRT. We matched 76 patients who did not show RR (RR−) to 80 RR+ control subjects by age, sex, HF etiology, New York Heart Association (NYHA) functional class and left ventricular ejection fraction (LVEF). The frequency of the minor allele of the NR3C2 gene (rs5522 C/T), encoding the mineralocorticoid receptor, was higher in RR− than in RR (24/126 vs 10/150; P value after false discovery rate correction: <.0193). Conversely, LVESV decreased significantly less after CRT in carriers of the NR3C2 minor C allele ( P = .02). After adjustment for age, sex, NYHA functional class, previous myocardial infarction, atrial fibrillation, and LVEF, RR− remained independently associated with NR3C2 C allele carriage (odds ratio 3.093, 95% confidence interval 1.253–7.632). Conclusions The association of RR− after CRT with a common polymorphism in the mineralocorticoid receptor gene involved in aldosterone signaling suggests a possible role for variants in RAAS genes in progressive LV function decline, despite apparently effective CRT.</description><identifier>ISSN: 1071-9164</identifier><identifier>EISSN: 1532-8414</identifier><identifier>DOI: 10.1016/j.cardfail.2012.07.008</identifier><identifier>PMID: 23040111</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Cardiac Resynchronization Therapy ; Cardiovascular ; Case-Control Studies ; Confidence Intervals ; Female ; Genetic Variation ; Heart failure ; Heart Failure - diagnostic imaging ; Heart Failure - genetics ; Heart Failure - therapy ; Humans ; Male ; Middle Aged ; mineralocorticoid receptor ; NR3C2 ; Odds Ratio ; Phenotype ; Pilot Projects ; Receptors, Mineralocorticoid - genetics ; Renin-Angiotensin System - genetics ; reverse remodeling ; Statistics as Topic ; Ultrasonography ; Ventricular Remodeling - genetics</subject><ispartof>Journal of cardiac failure, 2012-10, Vol.18 (10), p.762-768</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-813e84859b875c14f1e95c8832de5b318ce7041d5210f69797da3c71a30bc4883</citedby><cites>FETCH-LOGICAL-c423t-813e84859b875c14f1e95c8832de5b318ce7041d5210f69797da3c71a30bc4883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cardfail.2012.07.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23040111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Maria, Renata, MD</creatorcontrib><creatorcontrib>Landolina, Maurizio, MD</creatorcontrib><creatorcontrib>Gasparini, Maurizio, MD</creatorcontrib><creatorcontrib>Schmitz, Boris, PhD</creatorcontrib><creatorcontrib>Campolo, Jonica, MSc</creatorcontrib><creatorcontrib>Parolini, Marina, BStat</creatorcontrib><creatorcontrib>Sanzo, Antonio, MD</creatorcontrib><creatorcontrib>Galimberti, Paola, MD</creatorcontrib><creatorcontrib>Bianchi, Michele, MD</creatorcontrib><creatorcontrib>Brand, Stefan-Martin, MD, PhD</creatorcontrib><creatorcontrib>Parodi, Oberdan, MD</creatorcontrib><creatorcontrib>Lunati, Maurizio, MD</creatorcontrib><title>Genetic Variants of the Renin-Angiotensin-Aldosterone System and Reverse Remodeling After Cardiac Resynchronization Therapy</title><title>Journal of cardiac failure</title><addtitle>J Card Fail</addtitle><description>Abstract Background Reverse remodeling (RR) after cardiac resynchronization therapy (CRT) is associated with favorable clinical outcomes in heart failure (HF). The renin-angiotensin-aldosterone system (RAAS) is involved in the remodeling process. Methods and Results We assessed the association between RR and 8 common RAAS gene variants, which were determined by TaqMan assays, in 156 outpatients with chronic HF. RR was defined as a >15% decrease in left ventricular end systolic volume (LVESV) at 9 (interquartile range 7–12) months after CRT. We matched 76 patients who did not show RR (RR−) to 80 RR+ control subjects by age, sex, HF etiology, New York Heart Association (NYHA) functional class and left ventricular ejection fraction (LVEF). The frequency of the minor allele of the NR3C2 gene (rs5522 C/T), encoding the mineralocorticoid receptor, was higher in RR− than in RR (24/126 vs 10/150; P value after false discovery rate correction: <.0193). Conversely, LVESV decreased significantly less after CRT in carriers of the NR3C2 minor C allele ( P = .02). After adjustment for age, sex, NYHA functional class, previous myocardial infarction, atrial fibrillation, and LVEF, RR− remained independently associated with NR3C2 C allele carriage (odds ratio 3.093, 95% confidence interval 1.253–7.632). Conclusions The association of RR− after CRT with a common polymorphism in the mineralocorticoid receptor gene involved in aldosterone signaling suggests a possible role for variants in RAAS genes in progressive LV function decline, despite apparently effective CRT.</description><subject>Aged</subject><subject>Cardiac Resynchronization Therapy</subject><subject>Cardiovascular</subject><subject>Case-Control Studies</subject><subject>Confidence Intervals</subject><subject>Female</subject><subject>Genetic Variation</subject><subject>Heart failure</subject><subject>Heart Failure - diagnostic imaging</subject><subject>Heart Failure - genetics</subject><subject>Heart Failure - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>mineralocorticoid receptor</subject><subject>NR3C2</subject><subject>Odds Ratio</subject><subject>Phenotype</subject><subject>Pilot Projects</subject><subject>Receptors, Mineralocorticoid - genetics</subject><subject>Renin-Angiotensin System - genetics</subject><subject>reverse remodeling</subject><subject>Statistics as Topic</subject><subject>Ultrasonography</subject><subject>Ventricular Remodeling - genetics</subject><issn>1071-9164</issn><issn>1532-8414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhiMEoqXwClWOXBI8sZM4F8RqVVqkSki0cLW89qTrJbEXO1spiIfhWfpkTLQtBy6cPJK_f8b-JsvOgZXAoHm3K42OttduKCsGVcnakjH5LDuFmleFFCCeU81aKDpoxEn2KqUdI0Kw9mV2UnEmGACcZr8u0ePkTP5NR6f9lPLQ59MW8y_onS9W_s6FCX1a6sGGNGEMHvObmarx4bf2lsh7jGlJjMHi4PxdvuqJy9f0QqcNXaTZmy0F3U89ueDz2y1GvZ9fZy96PSR883ieZV8_Xtyur4rrz5ef1qvrwoiKT4UEjlLIutvItjYgesCuNlLyymK94SANtkyArStgfdO1XWs1Ny1ozjZGEHeWvT323cfw44BpUqNLBodBewyHpIB1tagb3nFCmyNqYkgpYq_20Y06zgSpxbzaqSfzajGvWKvIKwXPH2ccNiPav7En1QR8OAJIP713GFUyDr1B6yKaSdng_j_j_T8tDOl2Rg_fcca0C4foyaMClSijbpb9L-uHitKskfwPJ1-unA</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>De Maria, Renata, MD</creator><creator>Landolina, Maurizio, MD</creator><creator>Gasparini, Maurizio, MD</creator><creator>Schmitz, Boris, PhD</creator><creator>Campolo, Jonica, MSc</creator><creator>Parolini, Marina, BStat</creator><creator>Sanzo, Antonio, MD</creator><creator>Galimberti, Paola, MD</creator><creator>Bianchi, Michele, MD</creator><creator>Brand, Stefan-Martin, MD, PhD</creator><creator>Parodi, Oberdan, MD</creator><creator>Lunati, Maurizio, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Genetic Variants of the Renin-Angiotensin-Aldosterone System and Reverse Remodeling After Cardiac Resynchronization Therapy</title><author>De Maria, Renata, MD ; Landolina, Maurizio, MD ; Gasparini, Maurizio, MD ; Schmitz, Boris, PhD ; Campolo, Jonica, MSc ; Parolini, Marina, BStat ; Sanzo, Antonio, MD ; Galimberti, Paola, MD ; Bianchi, Michele, MD ; Brand, Stefan-Martin, MD, PhD ; Parodi, Oberdan, MD ; Lunati, Maurizio, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-813e84859b875c14f1e95c8832de5b318ce7041d5210f69797da3c71a30bc4883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Cardiac Resynchronization Therapy</topic><topic>Cardiovascular</topic><topic>Case-Control Studies</topic><topic>Confidence Intervals</topic><topic>Female</topic><topic>Genetic Variation</topic><topic>Heart failure</topic><topic>Heart Failure - diagnostic imaging</topic><topic>Heart Failure - genetics</topic><topic>Heart Failure - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>mineralocorticoid receptor</topic><topic>NR3C2</topic><topic>Odds Ratio</topic><topic>Phenotype</topic><topic>Pilot Projects</topic><topic>Receptors, Mineralocorticoid - genetics</topic><topic>Renin-Angiotensin System - genetics</topic><topic>reverse remodeling</topic><topic>Statistics as Topic</topic><topic>Ultrasonography</topic><topic>Ventricular Remodeling - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Maria, Renata, MD</creatorcontrib><creatorcontrib>Landolina, Maurizio, MD</creatorcontrib><creatorcontrib>Gasparini, Maurizio, MD</creatorcontrib><creatorcontrib>Schmitz, Boris, PhD</creatorcontrib><creatorcontrib>Campolo, Jonica, MSc</creatorcontrib><creatorcontrib>Parolini, Marina, BStat</creatorcontrib><creatorcontrib>Sanzo, Antonio, MD</creatorcontrib><creatorcontrib>Galimberti, Paola, MD</creatorcontrib><creatorcontrib>Bianchi, Michele, MD</creatorcontrib><creatorcontrib>Brand, Stefan-Martin, MD, PhD</creatorcontrib><creatorcontrib>Parodi, Oberdan, MD</creatorcontrib><creatorcontrib>Lunati, Maurizio, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiac failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Maria, Renata, MD</au><au>Landolina, Maurizio, MD</au><au>Gasparini, Maurizio, MD</au><au>Schmitz, Boris, PhD</au><au>Campolo, Jonica, MSc</au><au>Parolini, Marina, BStat</au><au>Sanzo, Antonio, MD</au><au>Galimberti, Paola, MD</au><au>Bianchi, Michele, MD</au><au>Brand, Stefan-Martin, MD, PhD</au><au>Parodi, Oberdan, MD</au><au>Lunati, Maurizio, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Variants of the Renin-Angiotensin-Aldosterone System and Reverse Remodeling After Cardiac Resynchronization Therapy</atitle><jtitle>Journal of cardiac failure</jtitle><addtitle>J Card Fail</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>18</volume><issue>10</issue><spage>762</spage><epage>768</epage><pages>762-768</pages><issn>1071-9164</issn><eissn>1532-8414</eissn><abstract>Abstract Background Reverse remodeling (RR) after cardiac resynchronization therapy (CRT) is associated with favorable clinical outcomes in heart failure (HF). The renin-angiotensin-aldosterone system (RAAS) is involved in the remodeling process. Methods and Results We assessed the association between RR and 8 common RAAS gene variants, which were determined by TaqMan assays, in 156 outpatients with chronic HF. RR was defined as a >15% decrease in left ventricular end systolic volume (LVESV) at 9 (interquartile range 7–12) months after CRT. We matched 76 patients who did not show RR (RR−) to 80 RR+ control subjects by age, sex, HF etiology, New York Heart Association (NYHA) functional class and left ventricular ejection fraction (LVEF). The frequency of the minor allele of the NR3C2 gene (rs5522 C/T), encoding the mineralocorticoid receptor, was higher in RR− than in RR (24/126 vs 10/150; P value after false discovery rate correction: <.0193). Conversely, LVESV decreased significantly less after CRT in carriers of the NR3C2 minor C allele ( P = .02). After adjustment for age, sex, NYHA functional class, previous myocardial infarction, atrial fibrillation, and LVEF, RR− remained independently associated with NR3C2 C allele carriage (odds ratio 3.093, 95% confidence interval 1.253–7.632). Conclusions The association of RR− after CRT with a common polymorphism in the mineralocorticoid receptor gene involved in aldosterone signaling suggests a possible role for variants in RAAS genes in progressive LV function decline, despite apparently effective CRT.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23040111</pmid><doi>10.1016/j.cardfail.2012.07.008</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1071-9164 |
| ispartof | Journal of cardiac failure, 2012-10, Vol.18 (10), p.762-768 |
| issn | 1071-9164 1532-8414 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1095456393 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Cardiac Resynchronization Therapy Cardiovascular Case-Control Studies Confidence Intervals Female Genetic Variation Heart failure Heart Failure - diagnostic imaging Heart Failure - genetics Heart Failure - therapy Humans Male Middle Aged mineralocorticoid receptor NR3C2 Odds Ratio Phenotype Pilot Projects Receptors, Mineralocorticoid - genetics Renin-Angiotensin System - genetics reverse remodeling Statistics as Topic Ultrasonography Ventricular Remodeling - genetics |
| title | Genetic Variants of the Renin-Angiotensin-Aldosterone System and Reverse Remodeling After Cardiac Resynchronization Therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T19%3A50%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20Variants%20of%20the%20Renin-Angiotensin-Aldosterone%20System%C2%A0and%20Reverse%20Remodeling%20After%20Cardiac%20Resynchronization%20Therapy&rft.jtitle=Journal%20of%20cardiac%20failure&rft.au=De%20Maria,%20Renata,%20MD&rft.date=2012-10-01&rft.volume=18&rft.issue=10&rft.spage=762&rft.epage=768&rft.pages=762-768&rft.issn=1071-9164&rft.eissn=1532-8414&rft_id=info:doi/10.1016/j.cardfail.2012.07.008&rft_dat=%3Cproquest_cross%3E1095456393%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1095456393&rft_id=info:pmid/23040111&rft_els_id=1_s2_0_S1071916412008068&rfr_iscdi=true |