Genetic Variants of the Renin-Angiotensin-Aldosterone System and Reverse Remodeling After Cardiac Resynchronization Therapy

Abstract Background Reverse remodeling (RR) after cardiac resynchronization therapy (CRT) is associated with favorable clinical outcomes in heart failure (HF). The renin-angiotensin-aldosterone system (RAAS) is involved in the remodeling process. Methods and Results We assessed the association betwe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cardiac failure 2012-10, Vol.18 (10), p.762-768
Hauptverfasser:	De Maria, Renata, MD, Landolina, Maurizio, MD, Gasparini, Maurizio, MD, Schmitz, Boris, PhD, Campolo, Jonica, MSc, Parolini, Marina, BStat, Sanzo, Antonio, MD, Galimberti, Paola, MD, Bianchi, Michele, MD, Brand, Stefan-Martin, MD, PhD, Parodi, Oberdan, MD, Lunati, Maurizio, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Cardiac Resynchronization Therapy Cardiovascular Case-Control Studies Confidence Intervals Female Genetic Variation Heart failure Heart Failure - diagnostic imaging Heart Failure - genetics Heart Failure - therapy Humans Male Middle Aged mineralocorticoid receptor NR3C2 Odds Ratio Phenotype Pilot Projects Receptors, Mineralocorticoid - genetics Renin-Angiotensin System - genetics reverse remodeling Statistics as Topic Ultrasonography Ventricular Remodeling - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Background Reverse remodeling (RR) after cardiac resynchronization therapy (CRT) is associated with favorable clinical outcomes in heart failure (HF). The renin-angiotensin-aldosterone system (RAAS) is involved in the remodeling process. Methods and Results We assessed the association between RR and 8 common RAAS gene variants, which were determined by TaqMan assays, in 156 outpatients with chronic HF. RR was defined as a >15% decrease in left ventricular end systolic volume (LVESV) at 9 (interquartile range 7–12) months after CRT. We matched 76 patients who did not show RR (RR−) to 80 RR+ control subjects by age, sex, HF etiology, New York Heart Association (NYHA) functional class and left ventricular ejection fraction (LVEF). The frequency of the minor allele of the NR3C2 gene (rs5522 C/T), encoding the mineralocorticoid receptor, was higher in RR− than in RR (24/126 vs 10/150; P value after false discovery rate correction:
ISSN:	1071-9164 1532-8414
DOI:	10.1016/j.cardfail.2012.07.008