PPAR-ϒ Pathway to Vascular Dysfunction

PPAR-ϒ Pathway to Vascular Dysfunction

Humans with dominant-negative (DN) mutations in PPAR-ϒ develop early onset hypertension. A recent study by Pelham et al. (2012) shows that loss of PPAR-ϒ repression of the Rho kinase pathway leads to altered vascular function via a smooth-muscle-dependent pathway that is independent of NO and oxidan...

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Veröffentlicht in:Cell metabolism 2012-10, Vol.16 (4), p.410-411
Hauptverfasser: Lombard, Julian H., Cowley, Allen W.
Format: Artikel
Sprache:eng
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Zusammenfassung:Humans with dominant-negative (DN) mutations in PPAR-ϒ develop early onset hypertension. A recent study by Pelham et al. (2012) shows that loss of PPAR-ϒ repression of the Rho kinase pathway leads to altered vascular function via a smooth-muscle-dependent pathway that is independent of NO and oxidant stress.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2012.09.010