Role and regulation of VEGF and its receptors 1 and 2 in the aseptic loosening of total hip implants

It was hypothesized that vascular endothelial growth factor (VEGF) in fibroblasts participates in aseptic loosening of total hip replacement (THR) implants. Therefore, osteoarthritic (OA) samples (n = 11) were compared with synovial membrane‐like interface tissues from revision THR (n = 10). VEGF‐A...

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Veröffentlicht in:	Journal of orthopaedic research 2012-11, Vol.30 (11), p.1830-1836
Hauptverfasser:	Waris, Ville, Sillat, Tarvo, Waris, Eero, Virkki, Liisa, Mandelin, Jami, Takagi, Michiaki, Konttinen, Yrjö T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Arthroplasty, Replacement, Hip aseptic loosening Cell Line Cytokines Female Fibroblasts - metabolism Humans hypoxia Hypoxia - metabolism Male Middle Aged osteoarthritis Osteoarthritis, Hip - metabolism Osteoarthritis, Hip - pathology Prosthesis Failure Rabbits Reoperation Synovial Membrane - pathology total hip replacement Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF
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Zusammenfassung:	It was hypothesized that vascular endothelial growth factor (VEGF) in fibroblasts participates in aseptic loosening of total hip replacement (THR) implants. Therefore, osteoarthritic (OA) samples (n = 11) were compared with synovial membrane‐like interface tissues from revision THR (n = 10). VEGF‐A and its receptors were stained using streptavidin‐immunoperoxidase method. Their regulation by hypoxia and cytokines were studied in cultured fibroblasts using quantitative real‐time polymerase chain reaction (qRT‐PCR). VEGFR1+ lining cells (p
ISSN:	0736-0266 1554-527X
DOI:	10.1002/jor.22138