Artificial Signal Transduction with Primary and Secondary Messengers

The complete, entirely artificial, signal‐transduction process was realized with a pair of tailored transmembrane units that were equipped with receptor‐ and reactive sites at both amphiphilic ends. Thus, docking of the primary messenger, transmission of the signal, and release of the secondary mess...

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Veröffentlicht in:Chemistry : a European journal 2012-10, Vol.18 (42), p.13412-13417
Hauptverfasser: Bernitzki, Kai, Maue, Michael, Schrader, Thomas
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container_issue 42
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container_title Chemistry : a European journal
container_volume 18
creator Bernitzki, Kai
Maue, Michael
Schrader, Thomas
description The complete, entirely artificial, signal‐transduction process was realized with a pair of tailored transmembrane units that were equipped with receptor‐ and reactive sites at both amphiphilic ends. Thus, docking of the primary messenger, transmission of the signal, and release of the secondary messenger could all be imitated in a single experimental setup. The system imitates the signaling principle of receptor tyrosine kinases and employs bisphosphonate head‐groups for oligoamine‐recognition and a pair of thiol nucleophiles and pyridine disulfide tail‐groups for intravesicle SN2 displacement. This system operates in a unidirectional fashion, does not suffer from intervesicle competition, and is highly sensitive towards the lipid composition of the membrane and the nature of the primary messenger. Don't shoot the messenger: The complete process of entirely artificial signal transduction was realized with a pair of tailored transmembrane units that were equipped with receptor and reactive sites at both amphiphilic ends (see figure). Thus, docking of the primary messenger, transmission of the signal, and release of the secondary messenger could all be imitated in a single experimental setup.
doi_str_mv 10.1002/chem.201200623
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subjects 1,2-Dipalmitoylphosphatidylcholine - chemistry
amphiphiles
Chemistry
Dimyristoylphosphatidylcholine - chemistry
Fluorescence Resonance Energy Transfer
host-guest systems
Lipid Bilayers - chemistry
membranes
messengers
Oxidation-Reduction
Proteins
Pyridines - chemistry
Signal Transduction
Sulfhydryl Compounds - chemistry
title Artificial Signal Transduction with Primary and Secondary Messengers
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