Solving the mystery of procollagen chain selectivity

Solving the mystery of procollagen chain selectivity

The recently solved crystal structure of the procollagen C propeptide reveals the basis for chain selectivity as well as an unexpected asymmetry to this homotrimeric molecule. In addition, mapping disease-causing mutations to the structure demonstrates clear correlation between severity of disease a...

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Veröffentlicht in:Nature structural & molecular biology 2012-10, Vol.19 (10), p.977-978
1. Verfasser: Bulleid, Neil J
Format: Artikel
Sprache:eng
Schlagworte:
631/45/535
631/92/60
Biochemistry
Biological Microscopy
Collagen
Collagen Diseases - genetics
Collagen Type III - chemistry
Collagen Type III - metabolism
Crystal structure
Gene mutations
Humans
Identification and classification
Life Sciences
Membrane Biology
Molecular biology
Mutation
news-and-views
Peptides
Properties
Protein Structure
Proteins
Structure
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Beschreibung
Zusammenfassung:The recently solved crystal structure of the procollagen C propeptide reveals the basis for chain selectivity as well as an unexpected asymmetry to this homotrimeric molecule. In addition, mapping disease-causing mutations to the structure demonstrates clear correlation between severity of disease and mutation location.
ISSN:1545-9993
1545-9985
DOI:10.1038/nsmb.2397