Silver-Catalyzed Intramolecular Aminofluorination of Activated Allenes

A nice combination: The intramolecular oxidative aminofluorination of allenes using silver catalysis and FN(SO2Ph)2 as the fluorinating reagent has been developed. This reaction represents an efficient method for the synthesis of various 4‐fluoro‐2,5‐dihydropyrrole compounds. Further transformation...

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Veröffentlicht in:	Angewandte Chemie International Edition 2011-08, Vol.50 (35), p.8176-8179
Hauptverfasser:	Xu, Tao, Mu, Xin, Peng, Haihui, Liu, Guosheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkadienes - chemistry allenes aminofluorination Catalysis Cyclization fluorinated heterocycles Fluorine - chemistry Halogenation oxidation Oxidation-Reduction Pyrroles - chemistry silver Silver - chemistry
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Beschreibung
Zusammenfassung:	A nice combination: The intramolecular oxidative aminofluorination of allenes using silver catalysis and FN(SO2Ph)2 as the fluorinating reagent has been developed. This reaction represents an efficient method for the synthesis of various 4‐fluoro‐2,5‐dihydropyrrole compounds. Further transformation provided the corresponding fluorinated pyrrole derivatives in good yields (see scheme).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201103225