A Fatal Overdose With Colchicine

A Fatal Overdose With Colchicine

A colchicine blood concentration of 250 µg/L was determined in a 39-year-old white female 2 hours following the ingestion of an oral overdose of the drug. At death, 40 hours following ingestion, no drug was detected. Colchicine was extracted from buffered blood using dichloromethane. The evaporated...

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Veröffentlicht in:Journal of analytical toxicology 1980-05, Vol.4 (3), p.153-155
Hauptverfasser: Caplan, Yale H., Orloff, Kenneth G., Thompson, Bernard C.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Blood
Blood levels
Chromatography, High Pressure Liquid - methods
Colchicine
Colchicine - blood
Colchicine - poisoning
Dichloromethane
Drugs
Female
Humans
Overdose
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Beschreibung
Zusammenfassung:A colchicine blood concentration of 250 µg/L was determined in a 39-year-old white female 2 hours following the ingestion of an oral overdose of the drug. At death, 40 hours following ingestion, no drug was detected. Colchicine was extracted from buffered blood using dichloromethane. The evaporated extract was redissolved in 0.1 N HCl and analyzed using a high performance liquid Chromatograph equipped with an octadecylsilane reversed phase column.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/4.3.153