High IL-10 production by aged AIDS patients is related to high frequency of Tr-1 phenotype and low in vitro viral replication

Abstract This work aims to elucidate the effects of age and HIV-1 infection on the frequency and function of T cell subsets in response to HIV-specific and non-specific stimuli. As compared with the younger AIDS group, the frequencies of naive and central memory T cells were significantly lower in a...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2012-10, Vol.145 (1), p.31-43
Hauptverfasser:	Andrade, Regis M, Hygino, Joana, Kasahara, Taissa M, Vieira, Morgana M, Xavier, Luciana F, Blanco, Bernardo, Damasco, Paulo V, Silva, Rodrigo M, Lima, Dirce B, Oliveira, Ariane L, Lemos, Alberto S, Andrade, Arnaldo F.B, Bento, Cleonice A.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - virology Adult Age Factors Aging Allergy and Immunology Anti-retroviral therapy Antibodies, Monoclonal - pharmacology Antiretroviral Therapy, Highly Active Antiviral Agents - administration & dosage Biological and medical sciences CD152 Cell culture Cells, Cultured Female FoxP3 Fundamental and applied biological sciences. Psychology Fundamental immunology HIV HIV-1 - drug effects HIV-1 - physiology Human immunodeficiency virus 1 Human viral diseases Humans IL-10 Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunologic Memory Immunological memory Immunopathology Immunophenotyping Infection Infectious diseases Interleukin 1 Interleukin 10 Interleukin 6 Interleukin-10 - antagonists & inhibitors Interleukin-10 - immunology Interleukin-1beta - biosynthesis Interleukin-1beta - immunology Interleukin-6 - biosynthesis Interleukin-6 - immunology Lymphocytes T Male Medical sciences Memory cells Middle Aged Monoclonal antibodies Peripheral blood mononuclear cells Replication T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - pathology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virus Replication - drug effects
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Zusammenfassung:	Abstract This work aims to elucidate the effects of age and HIV-1 infection on the frequency and function of T cell subsets in response to HIV-specific and non-specific stimuli. As compared with the younger AIDS group, the frequencies of naive and central memory T cells were significantly lower in aged AIDS patients. Although there was also a dramatic loss of classical CD4+ FoxP3+ CD25+ Treg cells in this patient group, high frequencies of IL-10-producing CD4+ FoxP3− T cells were observed. In our system, the increased production of IL-10 in aged AIDS patients was mainly derived from Env-specific CD4+ FoxP3− CD152+ T cells. Interestingly, while the blockade of IL-10 activity by monoclonal antibody clearly enhanced the release of IL-6 and IL-1β by Env-stimulated PBMC cultures from aged AIDS patients, this monoclonal antibody enhanced in vitro HIV-1-replication. In conclusion, HIV infection and aging undoubtedly contribute synergistically to a complex immune dysfunction in T cell compartment of HAART-treated older HIV-infected individuals.
ISSN:	1521-6616 1521-7035
DOI:	10.1016/j.clim.2012.08.002