Influence of hyperbaric oxygen therapy on peri-implant bone healing in rats with alloxan-induced diabetes

Aim The influence of hyperbaric oxygen therapy (HBOT) on peri‐implant bone healing in rats with alloxan‐induced type‐1 diabetes was studied. Materials and methods Forty‐eight male rats were randomly divided into six groups: (1) healthy rats (HR) that received no HBOT; (2) HR that underwent 10 sessions of HBOT before implant installation; (3) HR that underwent 10 sessions of HBOT after implant installation; (4) rats with induced diabetes (DR) without HBOT; (5) DR that underwent 10 sessions of HBOT before implant installation; (6) DR that underwent 10 sessions of HBOT after implant installation. A screw‐shaped titanium implant was inserted into the femur. The animals were killed 28 days after implantation. The percentage of bone‐to‐implant contact (BIC) within the implant threads was evaluated. Results Lower BIC was observed in DR (35.35 ± 18.04) compared with the HR (69.07 ± 09.01) (p = 0.001). However, with HBOT, either before or after implantation, BIC was increased in DR. HBOT before implantation was p = 0.03; HBOT after implantation was p = 0.08. This increase reversed the negative effect of diabetes; therefore, the differences between DR and HR were not significant with HBOT (p ≥ 0.21). Conclusion HBOT, either before or after implantation, increased the BIC in DR to the level of HR