Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis
The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent...
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| Veröffentlicht in: | Molecular neurobiology 2012-06, Vol.45 (3), p.605-620 |
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| creator | Wu, Jing Xiao, Haifan Sun, Hongjuan Zou, Li Zhu, Ling-Qiang |
| description | The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD. |
| doi_str_mv | 10.1007/s12035-012-8278-5 |
| format | Article |
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Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-012-8278-5</identifier><identifier>PMID: 22610946</identifier><language>eng</language><publisher>New York: Humana Press Inc</publisher><subject>Attention Deficit Disorder with Hyperactivity - genetics ; Attention Deficit Disorder with Hyperactivity - metabolism ; Attention deficit hyperactivity disorder ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell Biology ; Central nervous system ; Children ; Data processing ; Dopamine ; Dopamine D1 receptors ; Dopamine D2 receptors ; Dopamine D4 receptors ; Dopamine D5 receptors ; Dopamine receptors ; Gene polymorphism ; Genetic Predisposition to Disease ; Humans ; Mental disorders ; Meta-analysis ; Nervous system ; Neurobiology ; Neurology ; Neurosciences ; Polymorphism, Genetic ; Receptors, Dopamine - chemistry ; Receptors, Dopamine - genetics ; Receptors, Dopamine - metabolism ; Reviews ; Risk factors ; Systematic review</subject><ispartof>Molecular neurobiology, 2012-06, Vol.45 (3), p.605-620</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-99f324be82d8f91279f8dcc94cd4df14184d728b5ef2a04f2fec2ec93e544ff83</citedby><cites>FETCH-LOGICAL-c519t-99f324be82d8f91279f8dcc94cd4df14184d728b5ef2a04f2fec2ec93e544ff83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-012-8278-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-012-8278-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22610946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Jing</creatorcontrib><creatorcontrib>Xiao, Haifan</creatorcontrib><creatorcontrib>Sun, Hongjuan</creatorcontrib><creatorcontrib>Zou, Li</creatorcontrib><creatorcontrib>Zhu, Ling-Qiang</creatorcontrib><title>Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.</description><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Attention Deficit Disorder with Hyperactivity - metabolism</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Central nervous system</subject><subject>Children</subject><subject>Data processing</subject><subject>Dopamine</subject><subject>Dopamine D1 receptors</subject><subject>Dopamine D2 receptors</subject><subject>Dopamine D4 receptors</subject><subject>Dopamine D5 receptors</subject><subject>Dopamine receptors</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Mental disorders</subject><subject>Meta-analysis</subject><subject>Nervous system</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Dopamine - chemistry</subject><subject>Receptors, Dopamine - genetics</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Reviews</subject><subject>Risk factors</subject><subject>Systematic review</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUtLLDEQhYMoOj5-gJtLgxs30VQlmU5cXBgcX6AIPtZNJl2Rln7M7fQs5t8baZWLILiqRX3nFHUOY4cgTkCI_DQCCqm5AOQGc8P1BpuA1pYDGNxkE2Gs5PlUmR22G-OrEIgg8m22gzgFYdV0wv4-dDVlXcjm3dI1VUvZA3laDl0fs6rNZvPr-Vk2yx7XcaDGDZXP7mhw3LWuXscq7rOt4OpIBx9zjz1fXjydX_Pb-6ub89kt9xrswK0NEtWCDJYmWMDcBlN6b5UvVRlAgVFljmahKaATKmAgj-StJK1UCEbusePRd9l3_1YUh6Kpoqe6di11q1ikb6SaSpTyFyiCTXFBntCjb-hrt-rTayOlFGgpEgUj5fsuxp5CseyrxvXrBBXvPRRjD0XqoXjvodBJ8-fDebVoqPxSfAafAByBmFbtC_X_n_7J9Q2S94_H</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Wu, Jing</creator><creator>Xiao, Haifan</creator><creator>Sun, Hongjuan</creator><creator>Zou, Li</creator><creator>Zhu, Ling-Qiang</creator><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis</title><author>Wu, Jing ; Xiao, Haifan ; Sun, Hongjuan ; Zou, Li ; Zhu, Ling-Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-99f324be82d8f91279f8dcc94cd4df14184d728b5ef2a04f2fec2ec93e544ff83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Attention Deficit Disorder with Hyperactivity - genetics</topic><topic>Attention Deficit Disorder with Hyperactivity - metabolism</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Central nervous system</topic><topic>Children</topic><topic>Data processing</topic><topic>Dopamine</topic><topic>Dopamine D1 receptors</topic><topic>Dopamine D2 receptors</topic><topic>Dopamine D4 receptors</topic><topic>Dopamine D5 receptors</topic><topic>Dopamine receptors</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Mental disorders</topic><topic>Meta-analysis</topic><topic>Nervous system</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Dopamine - chemistry</topic><topic>Receptors, Dopamine - genetics</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Reviews</topic><topic>Risk factors</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jing</creatorcontrib><creatorcontrib>Xiao, Haifan</creatorcontrib><creatorcontrib>Sun, Hongjuan</creatorcontrib><creatorcontrib>Zou, Li</creatorcontrib><creatorcontrib>Zhu, Ling-Qiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - 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Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.</abstract><cop>New York</cop><pub>Humana Press Inc</pub><pmid>22610946</pmid><doi>10.1007/s12035-012-8278-5</doi><tpages>16</tpages></addata></record> |
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| ispartof | Molecular neurobiology, 2012-06, Vol.45 (3), p.605-620 |
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| subjects | Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - metabolism Attention deficit hyperactivity disorder Biomedical and Life Sciences Biomedicine Brain Cell Biology Central nervous system Children Data processing Dopamine Dopamine D1 receptors Dopamine D2 receptors Dopamine D4 receptors Dopamine D5 receptors Dopamine receptors Gene polymorphism Genetic Predisposition to Disease Humans Mental disorders Meta-analysis Nervous system Neurobiology Neurology Neurosciences Polymorphism, Genetic Receptors, Dopamine - chemistry Receptors, Dopamine - genetics Receptors, Dopamine - metabolism Reviews Risk factors Systematic review |
| title | Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis |
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