Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis

The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent...

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Veröffentlicht in:	Molecular neurobiology 2012-06, Vol.45 (3), p.605-620
Hauptverfasser:	Wu, Jing, Xiao, Haifan, Sun, Hongjuan, Zou, Li, Zhu, Ling-Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - metabolism Attention deficit hyperactivity disorder Biomedical and Life Sciences Biomedicine Brain Cell Biology Central nervous system Children Data processing Dopamine Dopamine D1 receptors Dopamine D2 receptors Dopamine D4 receptors Dopamine D5 receptors Dopamine receptors Gene polymorphism Genetic Predisposition to Disease Humans Mental disorders Meta-analysis Nervous system Neurobiology Neurology Neurosciences Polymorphism, Genetic Receptors, Dopamine - chemistry Receptors, Dopamine - genetics Receptors, Dopamine - metabolism Reviews Risk factors Systematic review
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Beschreibung
Zusammenfassung:	The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.
ISSN:	0893-7648 1559-1182
DOI:	10.1007/s12035-012-8278-5