Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells

Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells

Bisphenol A (BPA) is an estrogenic environmental toxin widely used for the production of plastics. Human frequent exposure to this chemical has been proposed to be a potential public health risk. The objective of this study was to assess the effects of BPA on DNA methylation of imprinting genes in f...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecular biology reports 2012-09, Vol.39 (9), p.8621-8628
Hauptverfasser: Zhang, Xi-Feng, Zhang, Lian-Jun, Feng, Yan-Ni, Chen, Bo, Feng, Yan-Min, Liang, Gui-Jin, Li, Lan, Shen, Wei
Format: Artikel
Sprache:eng
Schlagworte:
Air Pollutants, Occupational - pharmacology
Air Pollutants, Occupational - toxicity
Animal Anatomy
Animal Biochemistry
Animals
Benzhydryl Compounds
Biomedical and Life Sciences
CpG Islands
DNA methylation
DNA Methylation - drug effects
Environmental Exposure
Female
Fetus - drug effects
Gene Expression Regulation, Developmental - drug effects
Genes
Genomic Imprinting - drug effects
Germ Cells - drug effects
Germ Cells - metabolism
Germination
Histology
Kruppel-Like Transcription Factors - genetics
Life Sciences
Male
Mice
Morphology
Phenols - pharmacology
Phenols - toxicity
Pregnancy
Receptor, IGF Type 2 - genetics
Receptors, Estrogen - genetics
Rodents
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Bisphenol A (BPA) is an estrogenic environmental toxin widely used for the production of plastics. Human frequent exposure to this chemical has been proposed to be a potential public health risk. The objective of this study was to assess the effects of BPA on DNA methylation of imprinting genes in fetal mouse germ cell. Pregnant mice were treated with BPA at doses of 0, 40, 80 and 160 μg BPA/kg body weight/day from 0.5 day post coitum. DNA methylation of imprinting genes, Igf2r , Peg3 and H19 , was decreased with the increase of BPA concentration in fetal mouse germ cells ( p  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-012-1716-7