Pretreatment of Urine Samples for the Analysis of 11-nor- Delta D9-Tetrahydrocannabinol-9-Carboxylic Acid Using Solid-Phase Extraction

Pretreatment of Urine Samples for the Analysis of 11-nor- Delta D9-Tetrahydrocannabinol-9-Carboxylic Acid Using Solid-Phase Extraction

An extraction and concentration procedure using a unique solid-phase extraction tube was developed for the analysis of 11-nor- Delta *D9-tetrahydrocannabinol-9-carboxylic acid in urine. Absolute and relative recoveries of the drug metabolite were found to be greater than 85% and 92%, respectively. T...

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Veröffentlicht in:Journal of analytical toxicology 1990-01, Vol.14 (1), p.39-44
Hauptverfasser: Parry, Ritchard C, Nolan, Lydia, Shirey, Robert E, Wachob, George D, Gisch, Daryl J
Format: Artikel
Sprache:eng
Schlagworte:
Cannabis
Drugs
Guanylate cyclase
High-performance liquid chromatography
Ionization
Metabolites
Quantitation
Urine
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container_end_page 44
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container_title Journal of analytical toxicology
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creator Parry, Ritchard C
Nolan, Lydia
Shirey, Robert E
Wachob, George D
Gisch, Daryl J
description An extraction and concentration procedure using a unique solid-phase extraction tube was developed for the analysis of 11-nor- Delta *D9-tetrahydrocannabinol-9-carboxylic acid in urine. Absolute and relative recoveries of the drug metabolite were found to be greater than 85% and 92%, respectively. The extraction procedure allows quantitation of the drug metabolite by GC/MS, HPLC with UV detection, or GC with flame ionization detection. The extraction procedure was verified with urine samples obtained from marijuana users as well as spiked urine samples.
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source Oxford University Press Journals Digital Archive legacy; Alma/SFX Local Collection
subjects Cannabis
Drugs
Guanylate cyclase
High-performance liquid chromatography
Ionization
Metabolites
Quantitation
Urine
title Pretreatment of Urine Samples for the Analysis of 11-nor- Delta D9-Tetrahydrocannabinol-9-Carboxylic Acid Using Solid-Phase Extraction
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