Pretreatment of Urine Samples for the Analysis of 11-nor- Delta D9-Tetrahydrocannabinol-9-Carboxylic Acid Using Solid-Phase Extraction

Pretreatment of Urine Samples for the Analysis of 11-nor- Delta D9-Tetrahydrocannabinol-9-Carboxylic Acid Using Solid-Phase Extraction

An extraction and concentration procedure using a unique solid-phase extraction tube was developed for the analysis of 11-nor- Delta *D9-tetrahydrocannabinol-9-carboxylic acid in urine. Absolute and relative recoveries of the drug metabolite were found to be greater than 85% and 92%, respectively. T...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of analytical toxicology 1990-01, Vol.14 (1), p.39-44
Hauptverfasser: Parry, Ritchard C, Nolan, Lydia, Shirey, Robert E, Wachob, George D, Gisch, Daryl J
Format: Artikel
Sprache:eng
Schlagworte:
Cannabis
Drugs
Guanylate cyclase
High-performance liquid chromatography
Ionization
Metabolites
Quantitation
Urine
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An extraction and concentration procedure using a unique solid-phase extraction tube was developed for the analysis of 11-nor- Delta *D9-tetrahydrocannabinol-9-carboxylic acid in urine. Absolute and relative recoveries of the drug metabolite were found to be greater than 85% and 92%, respectively. The extraction procedure allows quantitation of the drug metabolite by GC/MS, HPLC with UV detection, or GC with flame ionization detection. The extraction procedure was verified with urine samples obtained from marijuana users as well as spiked urine samples.
ISSN:0146-4760