Diagnostic values of GHSR DNA methylation pattern in breast cancer

DNA methylation patterns have been recognised as cancer-specific markers with high potential for clinical applications. We aimed at identifying methylation variations that differentiate between breast cancers and other breast tissue entities to establish a signature for diagnosis. Candidate genomic...

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Veröffentlicht in:	Breast cancer research and treatment 2012-10, Vol.135 (3), p.705-713
Hauptverfasser:	Botla, Sandeep Kumar, Gholami, Amin Moghaddas, Malekpour, Mahdi, Moskalev, Evgeny A., Fallah, Mahdi, Jandaghi, Pouria, Aghajani, Ali, Bondar, Irina S., Omranipour, Ramesh, Malekpour, Fatemeh, Mohajeri, Abbas, Babadi, Azin Jahangiri, Sahin, Özgür, Bubnov, Vladimir V., Najmabadi, Hossein, Hoheisel, Jörg D., Riazalhosseini, Yasser
Format:	Artikel
Sprache:	eng
Schlagworte:	Benign Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cancer research Cancer therapies Cell culture Cell Line, Tumor CpG Islands Data processing Diagnosis DNA DNA Methylation DNA microarrays Down-Regulation Epigenesis, Genetic Epigenetics Female Gene Expression Regulation, Neoplastic Genes Genetic aspects genomics ghrelin Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical diagnosis Medical sciences Medicine Medicine & Public Health Membrane Proteins - genetics Methylation Microarray Analysis Oncology Preclinical Study Predictive Value of Tests Receptors, Ghrelin - genetics Receptors, Ghrelin - metabolism Reference Values Reproducibility of Results ROC Curve Sensitivity and Specificity Therapeutic applications Tumors
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Zusammenfassung:	DNA methylation patterns have been recognised as cancer-specific markers with high potential for clinical applications. We aimed at identifying methylation variations that differentiate between breast cancers and other breast tissue entities to establish a signature for diagnosis. Candidate genomic loci were analysed in 117 fresh-frozen breast specimens, which included cancer, benign and normal breast tissues from patients as well as material from healthy individuals. A cancer-specific DNA methylation signature was identified by microarray analysis in a test set of samples ( n = 52, p
ISSN:	0167-6806 1573-7217
DOI:	10.1007/s10549-012-2197-z