Short Term Dietary Fish Oil Supplementation Improves Motor Deficiencies Related to Reserpine-Induced Parkinsonism in Rats

Fish oil (FO) supplementation could cause an increase in the concentration of plasmatic free fatty acids and, consequently, could compete with pro-inflammatory arachidonic acid (ARA) derived from brain biomembranes metabolism in the cerebrospinal fluid. Essential fatty acids (EFA) (n-3) have been re...

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Veröffentlicht in:	Lipids 2011-02, Vol.46 (2), p.143-149
Hauptverfasser:	Barcelos, Raquel Cristine Silva, Benvegnú, Dalila Moter, Boufleur, Nardeli, Pase, Camila, Teixeira, Angélica Martelli, Reckziegel, Patrícia, Emanuelli, Tatiana, da Rocha, João Batista T., Bürger, Marilise Escobar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Arachidonic acid Basal ganglia Biomedical and Life Sciences Brain Catalepsy Catalepsy - chemically induced Catalepsy - physiopathology Catalepsy - prevention & control Central nervous system diseases Cerebrospinal fluid Cortex Dietary Supplements Disease Models, Animal Dyskinesia Fatty acids Fish oil Fish oils Fish Oils - administration & dosage Fish Oils - therapeutic use Life Sciences Lipid membranes Lipid peroxidation Lipidology Male Medical Biochemistry Medicinal Chemistry Metabolism Microbial Genetics and Genomics Motor disorders Movement disorders Movement Disorders - etiology Movement Disorders - physiopathology Movement Disorders - prevention & control Neostriatum Neurochemistry Neuroprotection Nutrition n‐3 Essential fatty acids Original Article Parkinsonian Disorders - chemically induced Parkinsonian Disorders - prevention & control Peroxidation Protective Agents - administration & dosage Protective Agents - therapeutic use Rats Rats, Wistar Reserpine Reserpine - toxicity
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Zusammenfassung:	Fish oil (FO) supplementation could cause an increase in the concentration of plasmatic free fatty acids and, consequently, could compete with pro-inflammatory arachidonic acid (ARA) derived from brain biomembranes metabolism in the cerebrospinal fluid. Essential fatty acids (EFA) (n-3) have been reported by their antioxidant and neuroprotective properties, and therefore the influence of the FO supplementation on the reserpine-induced motor disorders was studied. Wistar rats were orally treated with FO solution for 5 days, and co-treated with reserpine ( R ; 1 mg/kg/mL) or its vehicle for 3 days (every other day). Reserpine-induced orofacial dyskinesia and catalepsy ( P
ISSN:	0024-4201 1558-9307
DOI:	10.1007/s11745-010-3514-0