Tissue-Specific Expression of Splice Variants of Human IL-4 and IL-6 Gene mRNA

The spectrum of alternatively spliced IL-4 and IL-6 gene mRNA was studied in peripheral blood mononuclears from healthy donors and in human fetal tissues. It was found that the expression of alternatively spliced IL-4 and IL-6 gene mRNA in fetal tissues is tissue specific and that hemopoiesis- and i...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2012, Vol.152 (3), p.329-332
Hauptverfasser:	Yatsenko, O. P., Silkov, A. N., Khrapov, E. A., Filipenko, M. L., Kozlov, V. A., Sennikov, S. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Biomedical and Life Sciences Biomedicine Cell Biology Cytokines DNA Primers - genetics DNA, Complementary - biosynthesis Exons Fetus - metabolism Fetuses Genes Genetic engineering Genetic research Genetic translation Humans Immunology and Microbiology Interleukin 4 Interleukin 6 Interleukin-4 - genetics Interleukin-6 - genetics Internal Medicine Laboratory Medicine Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Messenger RNA mRNA Pathology Peripheral blood Protein Isoforms - genetics Proteins Real-Time Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism
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Zusammenfassung:	The spectrum of alternatively spliced IL-4 and IL-6 gene mRNA was studied in peripheral blood mononuclears from healthy donors and in human fetal tissues. It was found that the expression of alternatively spliced IL-4 and IL-6 gene mRNA in fetal tissues is tissue specific and that hemopoiesis- and immunopoiesis-related tissues differ by the amount of IL-4 and IL-4δ2 mRNA. An mRNA variant IL-4alt3 carrying partial exon 3 deletion was for the first time identified in human mononuclear cells.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-012-1520-3