Response calibration in neuroblastoma cultures over multielectrode array

Multielectrode Array (MEA) setups have been designed for direct culturing neural cells over silicon or glass substrates, providing the capability to stimulate and record simultaneously populations of neural cells. Neuroblastoma cultures over MEA have a very low signal/noise ratio response to stimulation, so it is difficult to detect small changes in spike activity in the culture during experiments. The main objective of this work is to study and to assess the statistical relevance of the response capabilities, with corresponding calibration or normalization, of neuroblastoma cultures to be used for hybrid systems.