Zinc release of Zn7-metallothionein-3 induces fibrillar type amyloid-[small beta] aggregates

Zinc release of Zn7-metallothionein-3 induces fibrillar type amyloid-[small beta] aggregates

The reactive oxygen species H2O2 promotes the Zn7-metallothionein-3 induced A[small beta]40 aggregation of fibrillar type structures via slow cysteine oxidation and Zn2+ release, whereas amorphous aggregates are formed by addition of Zn2+ to A[small beta]40.

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Veröffentlicht in:Metallomics 2010-01, Vol.2 (11), p.741-744
Hauptverfasser: Durand, Jade, Meloni, Gabriele, Talmard, Christine, Vasak, Milan, Faller, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Cysteine
Hydrogen peroxide
Oxidation
Reactive oxygen species
Zinc
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Zusammenfassung:The reactive oxygen species H2O2 promotes the Zn7-metallothionein-3 induced A[small beta]40 aggregation of fibrillar type structures via slow cysteine oxidation and Zn2+ release, whereas amorphous aggregates are formed by addition of Zn2+ to A[small beta]40.
ISSN:1756-5901
DOI:10.1039/C0MT00027B