The Effect of Monomer Order on the Hydrolysis of Biodegradable Poly(lactic-co-glycolic acid) Repeating Sequence Copolymers
The effect of sequence on copolymer properties is rarely studied despite the precedent from Nature that monomer order can create materials of significant diversity. Poly(lactic-co-glycolic acid) (PLGA), one of the most important biodegradable copolymers, is widely used in an unsequenced, random form...
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Veröffentlicht in: | Journal of the American Chemical Society 2012-10, Vol.134 (39), p.16352-16359 |
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creator | Li, Jian Rothstein, Sam N Little, Steven R Edenborn, Harry M Meyer, Tara Y |
description | The effect of sequence on copolymer properties is rarely studied despite the precedent from Nature that monomer order can create materials of significant diversity. Poly(lactic-co-glycolic acid) (PLGA), one of the most important biodegradable copolymers, is widely used in an unsequenced, random form for both drug delivery microparticles and tissue engineering matrices. Sequenced PLGA copolymers have been synthesized and fabricated into microparticles to study how their hydrolysis rates compare to those of random copolymers. Sequenced PLGA microparticles were found to degrade at slower, and often more constant, rates than random copolymers with the same lactic to glycolic acid ratios as demonstrated by molecular weight decrease, lactic acid release, and thermal property analyses. The impact of copolymer sequence on in vitro release was studied using PLGA microparticles loaded with model agent rhodamine-B. These assays established that copolymer sequence affects the rate of release and that a more gradual burst release can be achieved using sequenced copolymers compared to a random control. |
doi_str_mv | 10.1021/ja306866w |
format | Article |
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Poly(lactic-co-glycolic acid) (PLGA), one of the most important biodegradable copolymers, is widely used in an unsequenced, random form for both drug delivery microparticles and tissue engineering matrices. Sequenced PLGA copolymers have been synthesized and fabricated into microparticles to study how their hydrolysis rates compare to those of random copolymers. Sequenced PLGA microparticles were found to degrade at slower, and often more constant, rates than random copolymers with the same lactic to glycolic acid ratios as demonstrated by molecular weight decrease, lactic acid release, and thermal property analyses. The impact of copolymer sequence on in vitro release was studied using PLGA microparticles loaded with model agent rhodamine-B. 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Am. Chem. Soc</addtitle><description>The effect of sequence on copolymer properties is rarely studied despite the precedent from Nature that monomer order can create materials of significant diversity. Poly(lactic-co-glycolic acid) (PLGA), one of the most important biodegradable copolymers, is widely used in an unsequenced, random form for both drug delivery microparticles and tissue engineering matrices. Sequenced PLGA copolymers have been synthesized and fabricated into microparticles to study how their hydrolysis rates compare to those of random copolymers. Sequenced PLGA microparticles were found to degrade at slower, and often more constant, rates than random copolymers with the same lactic to glycolic acid ratios as demonstrated by molecular weight decrease, lactic acid release, and thermal property analyses. The impact of copolymer sequence on in vitro release was studied using PLGA microparticles loaded with model agent rhodamine-B. These assays established that copolymer sequence affects the rate of release and that a more gradual burst release can be achieved using sequenced copolymers compared to a random control.</description><subject>Biocompatible Materials - chemistry</subject><subject>Capsules</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>Hydrolysis</subject><subject>Lactic Acid - chemical synthesis</subject><subject>Lactic Acid - chemistry</subject><subject>Lactic Acid - metabolism</subject><subject>Polyglycolic Acid - chemical synthesis</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Rhodamines - chemistry</subject><subject>Rhodamines - metabolism</subject><subject>Temperature</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkFFLwzAUhYMobk4f_AOSF2F7qCbpmiaPOqYTJhOdzyVNb2dH29SkReqvN2O6J-GSy-V8OTc5CF1SckMJo7dbFRIuOP86QkMaMRJElPFjNCSEsCAWPBygM-e2fpwyQU_RgDEZkZjKIfpefwCe5znoFpscP5vaVGDxymb-NDVuvbzoM2vK3hVuh9wXJoONVZlKS8AvXhiXSreFDrQJNmWvTVlorHSRTfArNKDaot7gN_jsoNaAZ6bxV_wOd45OclU6uPjtI_T-MF_PFsFy9fg0u1sGKhS0DVQUR2mkJY3zqZSMCAW-GFMC0pRLGQmlJWEhkTlXkYgFy5lIve5FQngWjtB479tY4x_h2qQqnIayVDWYziWUCDYlseTMo5M9qq1xzkKeNLaolO09lOyiTg5Re_bq17ZLK8gO5F-2HrjeA0q7ZGs6W_tf_mP0A5fuhU8</recordid><startdate>20121003</startdate><enddate>20121003</enddate><creator>Li, Jian</creator><creator>Rothstein, Sam N</creator><creator>Little, Steven R</creator><creator>Edenborn, Harry M</creator><creator>Meyer, Tara Y</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121003</creationdate><title>The Effect of Monomer Order on the Hydrolysis of Biodegradable Poly(lactic-co-glycolic acid) Repeating Sequence Copolymers</title><author>Li, Jian ; Rothstein, Sam N ; Little, Steven R ; Edenborn, Harry M ; Meyer, Tara Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a381t-a575b5c917f499208ae8ae22a8ebb69958ac902309f6a58782f28b22ab69006d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biocompatible Materials - chemistry</topic><topic>Capsules</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Drug Carriers - chemistry</topic><topic>Hydrolysis</topic><topic>Lactic Acid - chemical synthesis</topic><topic>Lactic Acid - chemistry</topic><topic>Lactic Acid - metabolism</topic><topic>Polyglycolic Acid - chemical synthesis</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Rhodamines - chemistry</topic><topic>Rhodamines - metabolism</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Rothstein, Sam N</creatorcontrib><creatorcontrib>Little, Steven R</creatorcontrib><creatorcontrib>Edenborn, Harry M</creatorcontrib><creatorcontrib>Meyer, Tara Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jian</au><au>Rothstein, Sam N</au><au>Little, Steven R</au><au>Edenborn, Harry M</au><au>Meyer, Tara Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Monomer Order on the Hydrolysis of Biodegradable Poly(lactic-co-glycolic acid) Repeating Sequence Copolymers</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2012-10-03</date><risdate>2012</risdate><volume>134</volume><issue>39</issue><spage>16352</spage><epage>16359</epage><pages>16352-16359</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><abstract>The effect of sequence on copolymer properties is rarely studied despite the precedent from Nature that monomer order can create materials of significant diversity. Poly(lactic-co-glycolic acid) (PLGA), one of the most important biodegradable copolymers, is widely used in an unsequenced, random form for both drug delivery microparticles and tissue engineering matrices. Sequenced PLGA copolymers have been synthesized and fabricated into microparticles to study how their hydrolysis rates compare to those of random copolymers. 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source | MEDLINE; American Chemical Society Journals |
subjects | Biocompatible Materials - chemistry Capsules Drug Carriers - chemical synthesis Drug Carriers - chemistry Hydrolysis Lactic Acid - chemical synthesis Lactic Acid - chemistry Lactic Acid - metabolism Polyglycolic Acid - chemical synthesis Polyglycolic Acid - chemistry Rhodamines - chemistry Rhodamines - metabolism Temperature |
title | The Effect of Monomer Order on the Hydrolysis of Biodegradable Poly(lactic-co-glycolic acid) Repeating Sequence Copolymers |
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