The Effect of Monomer Order on the Hydrolysis of Biodegradable Poly(lactic-co-glycolic acid) Repeating Sequence Copolymers

The effect of sequence on copolymer properties is rarely studied despite the precedent from Nature that monomer order can create materials of significant diversity. Poly(lactic-co-glycolic acid) (PLGA), one of the most important biodegradable copolymers, is widely used in an unsequenced, random form...

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Veröffentlicht in:Journal of the American Chemical Society 2012-10, Vol.134 (39), p.16352-16359
Hauptverfasser: Li, Jian, Rothstein, Sam N, Little, Steven R, Edenborn, Harry M, Meyer, Tara Y
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container_end_page 16359
container_issue 39
container_start_page 16352
container_title Journal of the American Chemical Society
container_volume 134
creator Li, Jian
Rothstein, Sam N
Little, Steven R
Edenborn, Harry M
Meyer, Tara Y
description The effect of sequence on copolymer properties is rarely studied despite the precedent from Nature that monomer order can create materials of significant diversity. Poly(lactic-co-glycolic acid) (PLGA), one of the most important biodegradable copolymers, is widely used in an unsequenced, random form for both drug delivery microparticles and tissue engineering matrices. Sequenced PLGA copolymers have been synthesized and fabricated into microparticles to study how their hydrolysis rates compare to those of random copolymers. Sequenced PLGA microparticles were found to degrade at slower, and often more constant, rates than random copolymers with the same lactic to glycolic acid ratios as demonstrated by molecular weight decrease, lactic acid release, and thermal property analyses. The impact of copolymer sequence on in vitro release was studied using PLGA microparticles loaded with model agent rhodamine-B. These assays established that copolymer sequence affects the rate of release and that a more gradual burst release can be achieved using sequenced copolymers compared to a random control.
doi_str_mv 10.1021/ja306866w
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subjects Biocompatible Materials - chemistry
Capsules
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Hydrolysis
Lactic Acid - chemical synthesis
Lactic Acid - chemistry
Lactic Acid - metabolism
Polyglycolic Acid - chemical synthesis
Polyglycolic Acid - chemistry
Rhodamines - chemistry
Rhodamines - metabolism
Temperature
title The Effect of Monomer Order on the Hydrolysis of Biodegradable Poly(lactic-co-glycolic acid) Repeating Sequence Copolymers
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