Baculovirus as a vaccine vector
Baculovirus is extensively utilized as an excellent tool for production of recombinant protein in insect cells. Baculovirus infects insects in nature and is non-pathogenic to humans. In addition to insect cells, baculovirus is capable of transducing a broad range of animal cells. Due to its biosafet...
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| Veröffentlicht in: | Bioengineered 2012-09, Vol.3 (5), p.271-274 |
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| container_title | Bioengineered |
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| creator | Lu, Hsin-Yu Chen, Yi-Hsuan Liu, Hung-Jen |
| description | Baculovirus is extensively utilized as an excellent tool for production of recombinant protein in insect cells. Baculovirus infects insects in nature and is non-pathogenic to humans. In addition to insect cells, baculovirus is capable of transducing a broad range of animal cells. Due to its biosafety, large cloning capacity, low cytotoxicity, and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has been utilized as RNA interference mediators, gene delivery vectors, and vaccine vectors for a wide variety of applications. This article focuses on the utilization of baculoviruses as vaccine vectors to prepare antigen or subunit vaccines. |
| doi_str_mv | 10.4161/bioe.20679 |
| format | Article |
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Baculovirus infects insects in nature and is non-pathogenic to humans. In addition to insect cells, baculovirus is capable of transducing a broad range of animal cells. Due to its biosafety, large cloning capacity, low cytotoxicity, and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has been utilized as RNA interference mediators, gene delivery vectors, and vaccine vectors for a wide variety of applications. 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Baculovirus infects insects in nature and is non-pathogenic to humans. In addition to insect cells, baculovirus is capable of transducing a broad range of animal cells. Due to its biosafety, large cloning capacity, low cytotoxicity, and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has been utilized as RNA interference mediators, gene delivery vectors, and vaccine vectors for a wide variety of applications. This article focuses on the utilization of baculoviruses as vaccine vectors to prepare antigen or subunit vaccines.</description><subject>Animals</subject><subject>Baculoviridae - genetics</subject><subject>baculovirus</subject><subject>Binding</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cell Surface Display Techniques</subject><subject>Cells, Cultured</subject><subject>Cycle</subject><subject>Gene Transfer Techniques</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors</subject><subject>gp64</subject><subject>Humans</subject><subject>Insecta - cytology</subject><subject>Insecta - virology</subject><subject>Landes</subject><subject>Mini Review</subject><subject>Organogenesis</subject><subject>Proteins</subject><subject>Recombinant Proteins - biosynthesis</subject><subject>Recombinant Proteins - genetics</subject><subject>RNA Interference</subject><subject>surface display vector</subject><subject>Transduction, Genetic</subject><subject>vaccine</subject><subject>Vaccines, Subunit - biosynthesis</subject><subject>Vaccines, Subunit - genetics</subject><subject>VSVG</subject><issn>2165-5979</issn><issn>2165-5987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1rVDEQhoNYbKm98QfoXoqwNZOPk-RGcEu_oFBQex1yZudo5OzJmpyzpf_etNuuCkIhMIF53ndmXsbeAD9W0MDHNiY6Frwx7gU7ENDouXbWvNz9jdtnR6X85JwDl0ob-4rtC2G4tk4esHeLgFOfNjFPZRbqm20CYhxotiEcU37N9rrQFzp6rIfs5uz028nF_Or6_PLk89UcNYhxblqrwSKX2AVF3IVOWStBgbUaHZCmxkiwQpsGAZAM8iWSclw3ilzbykP2aeu7ntoV1d4w5tD7dY6rkO98CtH_2xniD_89bbxUxjROVYP3jwY5_ZqojH4VC1Lfh4HSVDxwK4RshBIV_bBFMadSMnW7McD9faj-PlT_EGqF3_692A59irACYgvUSUsqVVow0oC0Qx_cQh4j9n9c1TMiwUEsLq8XN-dfuQDzxa-XXZXprSwOXcqrcJtyv_RjuOtT7nIYMBYv_3PEb8hMqEM</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Lu, Hsin-Yu</creator><creator>Chen, Yi-Hsuan</creator><creator>Liu, Hung-Jen</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120901</creationdate><title>Baculovirus as a vaccine vector</title><author>Lu, Hsin-Yu ; Chen, Yi-Hsuan ; Liu, Hung-Jen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-7b8518c03cfa4e09af4883141885c91e5e673182576c11ce7c0dce490564e9bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Baculoviridae - genetics</topic><topic>baculovirus</topic><topic>Binding</topic><topic>Biology</topic><topic>Bioscience</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Cell Surface Display Techniques</topic><topic>Cells, Cultured</topic><topic>Cycle</topic><topic>Gene Transfer Techniques</topic><topic>Genetic Therapy - methods</topic><topic>Genetic Vectors</topic><topic>gp64</topic><topic>Humans</topic><topic>Insecta - cytology</topic><topic>Insecta - virology</topic><topic>Landes</topic><topic>Mini Review</topic><topic>Organogenesis</topic><topic>Proteins</topic><topic>Recombinant Proteins - biosynthesis</topic><topic>Recombinant Proteins - genetics</topic><topic>RNA Interference</topic><topic>surface display vector</topic><topic>Transduction, Genetic</topic><topic>vaccine</topic><topic>Vaccines, Subunit - biosynthesis</topic><topic>Vaccines, Subunit - genetics</topic><topic>VSVG</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Hsin-Yu</creatorcontrib><creatorcontrib>Chen, Yi-Hsuan</creatorcontrib><creatorcontrib>Liu, Hung-Jen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bioengineered</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Hsin-Yu</au><au>Chen, Yi-Hsuan</au><au>Liu, Hung-Jen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Baculovirus as a vaccine vector</atitle><jtitle>Bioengineered</jtitle><addtitle>Bioengineered</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>3</volume><issue>5</issue><spage>271</spage><epage>274</epage><pages>271-274</pages><issn>2165-5979</issn><eissn>2165-5987</eissn><abstract>Baculovirus is extensively utilized as an excellent tool for production of recombinant protein in insect cells. 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| ispartof | Bioengineered, 2012-09, Vol.3 (5), p.271-274 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Baculoviridae - genetics baculovirus Binding Biology Bioscience Calcium Cancer Cell Cell Surface Display Techniques Cells, Cultured Cycle Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors gp64 Humans Insecta - cytology Insecta - virology Landes Mini Review Organogenesis Proteins Recombinant Proteins - biosynthesis Recombinant Proteins - genetics RNA Interference surface display vector Transduction, Genetic vaccine Vaccines, Subunit - biosynthesis Vaccines, Subunit - genetics VSVG |
| title | Baculovirus as a vaccine vector |
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