Baculovirus as a vaccine vector

Baculovirus is extensively utilized as an excellent tool for production of recombinant protein in insect cells. Baculovirus infects insects in nature and is non-pathogenic to humans. In addition to insect cells, baculovirus is capable of transducing a broad range of animal cells. Due to its biosafet...

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Veröffentlicht in:Bioengineered 2012-09, Vol.3 (5), p.271-274
Hauptverfasser: Lu, Hsin-Yu, Chen, Yi-Hsuan, Liu, Hung-Jen
Format: Artikel
Sprache:eng
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Zusammenfassung:Baculovirus is extensively utilized as an excellent tool for production of recombinant protein in insect cells. Baculovirus infects insects in nature and is non-pathogenic to humans. In addition to insect cells, baculovirus is capable of transducing a broad range of animal cells. Due to its biosafety, large cloning capacity, low cytotoxicity, and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has been utilized as RNA interference mediators, gene delivery vectors, and vaccine vectors for a wide variety of applications. This article focuses on the utilization of baculoviruses as vaccine vectors to prepare antigen or subunit vaccines.
ISSN:2165-5979
2165-5987
DOI:10.4161/bioe.20679