A pH-responsive fluorescent probe and photosensitiser based on a self-quenched phthalocyanine dimer

A self-quenched zinc(II) phthalocyanine dimer linked with an acid-sensitive ketal unit has been prepared, which can be activated in an acidic environment (pH = 5.0-6.5) as a result of the cleavage of the ketal linker and separation of the phthalocyanine units, resulting in enhanced fluorescence emis...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2012-09, Vol.48 (72), p.9065-9067
Hauptverfasser:	Ke, Mei-Rong, Ng, Dennis K P, Lo, Pui-Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated Cleavage Dimerization Dimers Emission Fluorescence Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacology HT29 Cells Humans Hydrogen-Ion Concentration Indoles - chemistry Indoles - pharmacology Intracellular Space - drug effects Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Separation Singlet oxygen
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Beschreibung
Zusammenfassung:	A self-quenched zinc(II) phthalocyanine dimer linked with an acid-sensitive ketal unit has been prepared, which can be activated in an acidic environment (pH = 5.0-6.5) as a result of the cleavage of the ketal linker and separation of the phthalocyanine units, resulting in enhanced fluorescence emission and singlet oxygen production.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c2cc34327d