The influence of spasmolytic agents on heart rate variability and gastrointestinal motility in normal horses

The influence of spasmolytic agents on heart rate variability and gastrointestinal motility in normal horses

The effects of hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline) on heart rate (HR), HR variability (HRV) and gastrointestinal tract (GIT) contractions in the normal horse were determined. Five adult horses had ECG recordings for 180min after treatment with propantheline (...

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Veröffentlicht in:Research in veterinary science 2012-12, Vol.93 (3), p.1426-1433
Hauptverfasser: Sundra, T.M., Harrison, J.L., Lester, G.D., Raidal, S.L., Phillips, J.K.
Format: Artikel
Sprache:eng
Schlagworte:
adults
Animals
Autonomic
Butylscopolammonium Bromide - pharmacology
Cross-Over Studies
drug injection
drugs
gastrointestinal motility
Gastrointestinal Motility - drug effects
gastrointestinal system
Heart
Heart rate
Heart Rate - drug effects
Heart rate variability
Horses
Horses - physiology
Influence
Intestinal function
Motility
Muscarinic
Pain
Parasympatholytic
Parasympatholytics - pharmacology
Propantheline - pharmacology
spectral analysis
Standard deviation
Variables
Veterinary medicine
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Zusammenfassung:The effects of hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline) on heart rate (HR), HR variability (HRV) and gastrointestinal tract (GIT) contractions in the normal horse were determined. Five adult horses had ECG recordings for 180min after treatment with propantheline (100mg), hyoscine (120mg) or saline. Both propantheline and hyoscine reduced GIT sounds, with propantheline having a longer duration of effect (⩾120min). Both drugs elevated HR relative to the control baseline period (P
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2012.05.003