Telangiectatic osteosarcoma secondary to a liposclerosing myxofibrous tumor: a case report

Malignant transformation of a fibrous dysplasia into an osteosarcoma is very rare. We report the case of an 84-year-old man with telangiectatic osteosarcoma of the upper femur arising in a previous fibrous dysplasia also known as liposclerosing myxofibrous tumor. The tumor was expressing the epithel...

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Veröffentlicht in:	Annales de pathologie 2012-08, Vol.32 (4), p.259-262
Hauptverfasser:	Illac, Claire, Delisle, Marie-Bernadette, Bonnevialle, Paul, Chiavassa-Gandois, Hélène, de Pinieux, Gonzague, Gomez-Brouchet, Anne
Format:	Artikel
Sprache:	fre
Schlagworte:	Aged, 80 and over Biomarkers, Tumor - analysis Bone Cysts - etiology Bone Cysts - pathology Diagnosis, Differential Disease Progression Femoral Neoplasms - blood supply Femoral Neoplasms - chemistry Femoral Neoplasms - diagnosis Femoral Neoplasms - pathology Femoral Neoplasms - surgery Fibrous Dysplasia of Bone Hemorrhage - etiology Humans Magnetic Resonance Imaging Male Mucin-1 - analysis Neoplasms, Second Primary - blood supply Neoplasms, Second Primary - chemistry Neoplasms, Second Primary - diagnosis Neoplasms, Second Primary - pathology Neoplasms, Second Primary - surgery Osteosarcoma - blood supply Osteosarcoma - chemistry Osteosarcoma - diagnosis Osteosarcoma - pathology Osteosarcoma - surgery Solitary Fibrous Tumors - chemistry Solitary Fibrous Tumors - pathology Telangiectasis - pathology
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Zusammenfassung:	Malignant transformation of a fibrous dysplasia into an osteosarcoma is very rare. We report the case of an 84-year-old man with telangiectatic osteosarcoma of the upper femur arising in a previous fibrous dysplasia also known as liposclerosing myxofibrous tumor. The tumor was expressing the epithelial membrane antigen. This is the first described case of a malignant transformation into an osteosarcoma arising in a liposclerosing myxofibrous tumor. We discuss the main differential diagnosis with a review.
ISSN:	0242-6498
DOI:	10.1016/j.annpat.2012.06.003