Cytotoxicity evaluation of vancomycin and its complex with beta-cyclodextrin on human glial cell line

Cytotoxicity evaluation of vancomycin and its complex with beta-cyclodextrin on human glial cell line

The possible cytotoxic effects of vancomycin and its complex with beta-cyclodextrin (β-CD) on human glial cell line (CRL 8621) were studied accordingly by means of MTS assay. The cultured cells were incubated with various concentrations of vancomycin, β-CD as well as β-CD/vancomycin complex ranging...

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Veröffentlicht in:Pakistan journal of pharmaceutical sciences 2012-10, Vol.25 (4), p.831-837
Hauptverfasser: Sofian, Zarif Mohamed, Abdullah, Jafri Malin, Rahim, Afidah Abdul, Shafee, Shazrin Shazira, Mustafa, Zulkifli, Razak, Shariza Abdul
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - toxicity
beta-Cyclodextrins - chemistry
beta-Cyclodextrins - toxicity
Cell Line
Cell lines
Cell Survival - drug effects
Chemistry, Pharmaceutical
Cyclodextrins
Dosage and administration
Dose-Response Relationship, Drug
Drug Carriers
Health aspects
Humans
Inhibitory Concentration 50
Neuroglia - drug effects
Neuroglia - pathology
Pharmaceutical chemistry
Physiological aspects
Vancomycin
Vancomycin - chemistry
Vancomycin - toxicity
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Zusammenfassung:The possible cytotoxic effects of vancomycin and its complex with beta-cyclodextrin (β-CD) on human glial cell line (CRL 8621) were studied accordingly by means of MTS assay. The cultured cells were incubated with various concentrations of vancomycin, β-CD as well as β-CD/vancomycin complex ranging from 4.69 to 300 ug/ml. A linear dose-dependency cytotoxicity followed by hermetic-like biphasic dose-dependence was observed after incubation period of 72 hours. In general, significant increase (p
ISSN:1011-601X