Epidithiol Formation by an Unprecedented Twin Carbon-Sulfur Lyase in the Gliotoxin Pathway

Two in one go: The elucidation of a key step in the biosynthesis of gliotoxin, the infamous virulence factor of the human pathogen Aspergillus fumigatus, provides insight into the formation of an epidithiol. Isolation of a bis(cysteine) S‐conjugate from a ΔgliI mutant and in vitro studies show that...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-10, Vol.51 (40), p.10064-10068
Hauptverfasser: Scharf, Daniel H., Chankhamjon, Pranatchareeya, Scherlach, Kirstin, Heinekamp, Thorsten, Roth, Martin, Brakhage, Axel A., Hertweck, Christian
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Sprache:eng
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Zusammenfassung:Two in one go: The elucidation of a key step in the biosynthesis of gliotoxin, the infamous virulence factor of the human pathogen Aspergillus fumigatus, provides insight into the formation of an epidithiol. Isolation of a bis(cysteine) S‐conjugate from a ΔgliI mutant and in vitro studies show that GliI concomitantly cleaves two CS bonds, along with the formation of ammonia and pyruvate (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201205041