Effect of viral membrane fusion activity on antibody induction by influenza H5N1 whole inactivated virus vaccine

Highlights ► Formaldehyde treatment blocks fusion activity of WIV. ► Fusion inactivation of WIV reduces, but not block, TLR7-dependent IFNα induction. ► Fusion inactivation does not block WIV-induced IgG2c responses. ► Antibody affinity maturation is not affected by fusion inactivation of WIV....

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Veröffentlicht in:	Vaccine 2012-10, Vol.30 (45), p.6501-6507
Hauptverfasser:	Geeraedts, Felix, ter Veer, Wouter, Wilschut, Jan, Huckriede, Anke, de Haan, Aalzen
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Viral - blood Dendritic Cells - immunology Female Formaldehyde - pharmacology Fusion Hemagglutination Inhibition Tests IFNalpha Immune system Immunoglobulin G - blood Inactivation Influenza Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - immunology Interferon-alpha - immunology Medical research Membrane Glycoproteins - immunology Mice Mice, Inbred C57BL Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Pandemics Th1 Toll-Like Receptor 7 - immunology Vaccines Vaccines, Inactivated - immunology Virus Internalization - drug effects Whole inactivated virus vaccine
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Beschreibung
Zusammenfassung:	Highlights ► Formaldehyde treatment blocks fusion activity of WIV. ► Fusion inactivation of WIV reduces, but not block, TLR7-dependent IFNα induction. ► Fusion inactivation does not block WIV-induced IgG2c responses. ► Antibody affinity maturation is not affected by fusion inactivation of WIV.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.07.036