Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcomes reduced immunogenicity of the 2009 H1N1 strain

Highlights ► Reduced immunogenicity of the H1N1 component of the current TIV demonstrated. ► Reduced immunogenicity of the H1N1 component overcome by intradermal vaccination. ► Efficacy between two different intradermal devices compared. ► Superior efficacy of intradermal over conventional intramusc...

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Veröffentlicht in:	Vaccine 2012-10, Vol.30 (45), p.6427-6435
Hauptverfasser:	Hung, Ivan F.N, Levin, Yotam, To, Kelvin K.W, Chan, Kwok-Hung, Zhang, Anna Jinxia, Li, Patrick, Li, Clara, Xu, Ting, Wong, Tin-Yan, Yuen, Kwok-Yung
Format:	Artikel
Sprache:	eng
Schlagworte:	2009 H1N1 Aged Allergy and Immunology Antibodies, Viral - blood elderly Female hemagglutination Hemagglutination Inhibition Tests Hemagglutinin Glycoproteins, Influenza Virus - immunology hemagglutinins Humans Immunization Immunogenicity Influenza Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Influenza Vaccines - administration & dosage Influenza, Human - prevention & control Injections, Intradermal Intradermal Male Mortality Neutralization Tests Prospective Studies risk seroconversion vaccination Vaccination - methods Vaccine Vaccines
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Beschreibung
Zusammenfassung:	Highlights ► Reduced immunogenicity of the H1N1 component of the current TIV demonstrated. ► Reduced immunogenicity of the H1N1 component overcome by intradermal vaccination. ► Efficacy between two different intradermal devices compared. ► Superior efficacy of intradermal over conventional intramuscular vaccination demonstrated.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.08.014