A genome-wide single-nucleotide polymorphism-array can improve the prognostic stratification of the core binding factor acute myeloid leukemia

Core binding factor (CBF) AML with the D816 C‐KIT gene mutation demonstrate inferior treatment outcomes. However, the remaining cases without the D816 C‐KIT mutation imply a requirement of more sophisticated dissection of the patients according to their prognosis. In this study, we analyzed the prog...

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Veröffentlicht in:	American journal of hematology 2012-10, Vol.87 (10), p.961-968
Hauptverfasser:	Huh, Jungwon, Kim, Hee-Je, Jung, Chul Won, Kim, Hee-Jin, Kim, Sun-Hee, Kim, Yeo-Kyeoung, Kim, Hyeoung-Joon, Shin, Myung Geun, Moon, Joon Ho, Sohn, Sang Kyun, Kim, Sung Hyun, Lee, Won Sik, Won, Jong Ho, Mun, Yeung Chul, Kim, Hawk, Park, Jinny, Min, Woo Sung, Kim, Dong Hwan (Dennis)
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chromosome Inversion Core Binding Factors - genetics Cytarabine - administration & dosage Cytarabine - analogs & derivatives Disease-Free Survival Female Genome-Wide Association Study Hematologic and hematopoietic diseases Hematology Humans Idarubicin - administration & dosage Kaplan-Meier Estimate Karyotyping Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemia, Myeloid - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Neoplasm Proteins - genetics Polymorphism, Single Nucleotide Prognosis Proportional Hazards Models Proto-Oncogene Proteins c-kit - genetics Remission Induction Translocation, Genetic Young Adult
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