Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese

The genetic basis for susceptibility to malaria has been studied widely in African populations but less is known of the contribution of specific genetic variants in Asian populations. We genotyped 67 single-nucleotide polymorphisms (SNPs) in 1030 severe malaria cases and 2840 controls from Vietnam....

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Veröffentlicht in:	Genes and immunity 2012-09, Vol.13 (6), p.503-508
Hauptverfasser:	Dunstan, S J, Rockett, K A, Quyen, N T N, Teo, Y Y, Thai, C Q, Hang, N T, Jeffreys, A, Clark, T G, Small, K S, Simmons, C P, Day, N, O'Riordan, S E, Kwiatkowski, D P, Farrar, J, Phu, N H, Hien, T T
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205 631/208/457/649 692/699/255/1629 692/700/478/174 Adult Asian People - genetics Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Cell Adhesion Molecules - genetics Cohort Studies Consortia Female Gene Expression Genes Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Genetic Variation Human Genetics Humans Immunology Inflammation Mediators - immunology Intercellular Adhesion Molecule-1 - genetics Interleukin-13 - genetics Interleukin-1alpha - genetics Malaria Malaria, Falciparum - genetics Malaria, Falciparum - immunology Male Medicine Minority & ethnic groups original-article Parasitemia - genetics Parasitemia - immunology Physiological aspects Polymorphism, Single Nucleotide Receptors, Interleukin - genetics Risk factors Single nucleotide polymorphisms Success Tropical diseases Tumor Necrosis Factor-alpha - genetics Vaccines Vietnam Young Adult
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Zusammenfassung:	The genetic basis for susceptibility to malaria has been studied widely in African populations but less is known of the contribution of specific genetic variants in Asian populations. We genotyped 67 single-nucleotide polymorphisms (SNPs) in 1030 severe malaria cases and 2840 controls from Vietnam. After data quality control, genotyping data of 956 cases and 2350 controls were analysed for 65 SNPs (3 gender confirmation, 62 positioned in/near 42 malarial candidate genes). A total of 14 SNPs were monomorphic and 2 (rs8078340 and rs33950507) were not in Hardy–Weinberg equilibrium in controls ( P
ISSN:	1466-4879 1476-5470
DOI:	10.1038/gene.2012.25