Biomechanical effects of simulated resorption cavities in cancellous bone across a wide range of bone volume fractions

Resorption cavities formed during bone remodeling may act as “stress risers” and impair cancellous bone strength, but biomechanical analyses of the effects of stress risers have been limited. To provide further insight, we assessed the theoretical biomechanical effects of virtually‐added resorption cavities in cancellous bone specimens spanning a wide range of bone volume fraction (BV/TV = 0.05–0.36) and across different anatomic sites (hip and spine) and species (human and canine). Micro‐CT scans of 40 cubes of cancellous bone were converted into nonlinear finite element models (voxel element size ∼ 20 µm) for strength assessment. In each model, uniform trench‐like resorption cavities with nominal dimensions 500 µm (length) × 200 µm (width) × 40 µm (depth), were virtually added either at random locations throughout the specimen, or, preferentially at locations of high tissue‐level strain. We found that cancellous bone strength (p