Safety and efficacy of Gliadel wafers for newly diagnosed and recurrent glioblastoma

Safety and efficacy of Gliadel wafers for newly diagnosed and recurrent glioblastoma

Background Combining Gliadel wafers and radiochemotherapy with TMZ may carry the risk of increased adverse events (AE). We analyzed the efficacy and safety in patients with glioblastoma who underwent multimodal treatment with implantation of Gliadel wafers. Methods One hundred sixty-five consecutive...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta neurochirurgica 2012-08, Vol.154 (8), p.1371-1378
Hauptverfasser: De Bonis, Pasquale, Anile, Carmelo, Pompucci, Angelo, Fiorentino, Alba, Balducci, Mario, Chiesa, Silvia, Maira, Giulio, Mangiola, Annunziato
Format: Artikel
Sprache:eng
Schlagworte:
Adjuvants
Adult
Age
Aged
Aged, 80 and over
Antineoplastic Agents, Alkylating - therapeutic use
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Carmustine - adverse effects
Carmustine - therapeutic use
Clinical Article
Dacarbazine - adverse effects
Dacarbazine - analogs & derivatives
Dacarbazine - therapeutic use
Glioblastoma
Glioblastoma - mortality
Glioblastoma - pathology
Glioblastoma - therapy
Humans
Interventional Radiology
Male
Medicine
Medicine & Public Health
Middle Aged
Minimally Invasive Surgery
Multivariate analysis
Neoplasm Recurrence, Local - therapy
Neurology
Neuroradiology
Neurosurgery
Regression analysis
Surgery
Surgical Orthopedics
Survival
Toxicity
Treatment Outcome
Tumors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background Combining Gliadel wafers and radiochemotherapy with TMZ may carry the risk of increased adverse events (AE). We analyzed the efficacy and safety in patients with glioblastoma who underwent multimodal treatment with implantation of Gliadel wafers. Methods One hundred sixty-five consecutive patients with newly diagnosed (77 patients) or recurrent (88 patients) glioblastoma were studied. Forty-seven patients underwent surgery + Gliadel. The impact of age (≥65 vs.
ISSN:0001-6268
0942-0940
DOI:10.1007/s00701-012-1413-2